Results 171 to 180 of about 6,841 (192)

The role of HBV cccDNA in occult hepatitis B virus infection

Molecular and Cellular Biochemistry, 2023
Occult hepatitis B virus (HBV) infection (OBI) refers to the presence of replication-competent HBV DNA in the liver, with or without HBV DNA in the blood, in individuals who tested negative for HBV surface antigen (HBsAg). In this peculiar phase of HBV infection, the covalently closed circular DNA (cccDNA) is in a low state of replication.
Pei, He, Peixin, Zhang, Yaping, Fang, Ning, Han, Wensu, Yang, Zhaoxin, Xia, Yi, Zhu, Zhenhua, Zhang, Jilu, Shen   +8 more
openaire   +2 more sources

Inhibition of Hepatitis B virus cccDNA replication by siRNA

Biochemical and Biophysical Research Communications, 2007
The development of an effective therapy for Hepatitis B virus (HBV) infection is still a challenge. Progress in RNA interference (RNAi) has shed slight on developing a new anti-HBV strategy. Here, we present a series of experiments showing a significant reduction in HBV transcripts and replication intermediates in HepG2.2.15cells by vector-based siRNA ...
Gui-Qiu, Li, Hong-Xi, Gu, Di, Li, Wei-Zhen, Xu   +3 more
openaire   +2 more sources

IFN-α2b inhibits the ethanol enriched-HBV cccDNA through blocking a positive feedback loop of HBx/MSL2/cccDNA/HBV/HBx in liver

Biochemical and Biophysical Research Communications, 2020
Hepatitis B virus (HBV) is a major risk factor for liver diseases, in which HBV covalently closed circular DNA (cccDNA), as the genomic form that templates viral transcription, plays crucial roles in sustaining viral persistence. Clinically, the excessive ethanol intake accelerates the progression of liver diseases with HBV infection. Here, we supposed
Zixian Liu, Jiapei Wang, Hongfeng Yuan, Lei Liu, Yanan Bu, Man Zhao, Guang Yang, Jinyan Feng, Yunxia Liu, Jiangning Li, Qiujia He, Xiaodong Zhang   +11 more
openaire   +2 more sources

Inhibition of Hepatitis B Virus cccDNA by siRNA in Transgenic Mice

Cell Biochemistry and Biophysics, 2014
The elimination of viral covalently closed circular DNA (cccDNA) from the nucleus of infected hepatocytes is an obstacle to achieving sustained viral clearance during antiviral therapy of chronic hepatitis B virus (HBV) infection. The aim of our study was to determine whether treatment with siRNA is able to suppress viral cccDNA amplification using a ...
Guiqiu, Li, Guotao, Jiang, Juan, Lu, Shulan, Chen, Lanying, Cui, Jundong, Jiao, Yongchen, Wang   +6 more
openaire   +2 more sources

Targeting hepatitis B virus cccDNA using CRISPR/Cas9

Antiviral Research, 2015
Despite the existence of an excellent prophylactic vaccine and the development of highly effective inhibitors of the viral polymerase, chronic hepatitis B virus (HBV) infection remains a major source of morbidity and mortality, especially in Africa and Asia.
Edward M, Kennedy, Anand V R, Kornepati, Bryan R, Cullen   +2 more
openaire   +2 more sources

Eliminating cccDNA to cure hepatitis B virus infection

Journal of Hepatology, 2023
Zoulim, Fabien, Testoni, Barbara
openaire   +3 more sources

Targeting hepatitis B virus cccDNA levels: Recent progress in seeking small molecule drug candidates

Drug Discovery Today, 2023
Luis Menéndez-Arias, Xinyong Liu, Vasanthanathan Poongavanam   +2 more
exaly  

IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver

Acta Pharmacologica Sinica, 2021

exaly  

Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx

Journal of Hepatology, 2021
Juan Chen, Yuan Hu, Vincent Kam Wai Wong
exaly  

Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy1

Gastroenterology, 2004
Stephen Locarnini, Patrick Marcellin, Fabien Zoulim   +2 more
exaly