Results 1 to 10 of about 4,301 (202)

A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice [PDF]

npj Vaccines, 2021
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear.
John J. Suschak, Joseph W. Golden, Collin J. Fitzpatrick, Charles J. Shoemaker, Catherine V. Badger, Connie S. Schmaljohn, Aura R. Garrison   +6 more
doaj   +3 more sources

Genetic features of Orthonairovirus haemorrhagiae variants detected in ixodid ticks in Armenia. [PDF]

PLoS Neglected Tropical Diseases
IntroductionCrimean-Congo hemorrhagic fever (CCHF) is a viral transmissible febrile disease, featuring hemorrhagic manifestations and a high mortality rate, caused by Orthonairovirus haemorrhagiae (CCHFV).
Anna Volynkina, Yana Lisitskaya, Anna Zhirova, Olga Gnusareva, Ekaterina Vasilenko, Lyudmila Shaposhnikova, Sergey Pisarenko, Arsen Manucharyan, Gayane Melik-Andreasyan, Vladimir Dedkov, Anna Dolgova, Alexander Kulichenko   +11 more
doaj   +2 more sources

Crimean-Congo Hemorrhagic Fever Virus among Goats, Southern Bhutan [PDF]

Emerging Infectious Diseases
We conducted serosurveillance for Crimean-Congo hemorrhagic fever virus (CCHFV) among goats in southern Bhutan. Testing serum samples from 472 goats for CCHFV-specific IgG using an indirect fluorescent antibody test and ELISA, we found CCHFV antibody ...
Sangay Rinchen, Yoshihiro Kaku, Eunsil Park, Puspa Maya Sharma, Dawa Tshering, Tenzinla Tenzin, Aya Matsuu, Akiko Okutani, Ken Maeda, Shigeru Morikawa   +9 more
doaj   +2 more sources

Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

Frontiers in Veterinary Science, 2022
Crimean-Congo hemorrhagic fever (CCHF) is a priority emerging disease. CCHF, caused by the CCHF virus (CCHFV), can lead to hemorrhagic fever in humans with severe cases often having fatal outcomes. CCHFV is maintained within a tick-vertebrate-tick cycle,
Sandra Belij-Rammerstorfer, Georgina Limon, Emmanuel A. Maze, Kayleigh Hannant, Ellen Hughes, Simona R. Tchakarova, Tsviatko Alexandrov, Blandina T. Mmbaga, Blandina T. Mmbaga, Brian Willett, George Booth, Nicholas A. Lyons, Natalie Baker, Kelly M. Thomas, Daniel Wright, Jack Saunders, Clare Browning, Ginette Wilsden, Miles Carroll, Roger Hewson, Roger Hewson, Bryan Charleston, Teresa Lambe, Anna B. Ludi   +23 more
doaj   +1 more source

Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus

Frontiers in Cellular and Infection Microbiology, 2021
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease of global concerns due to the increasing incidence and lack of effective treatments.
Shiyu Dai, Qiaoli Wu, Xiaoli Wu, Cheng Peng, Jia Liu, Shuang Tang, Tao Zhang, Fei Deng, Shu Shen   +8 more
doaj   +1 more source

GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus

npj Vaccines, 2023
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic disease in humans. There is a great need for effective vaccines and therapeutics against CCHFV for humans, as none are currently internationally approved ...
Gabrielle Scher, Dennis A. Bente, Megan C. Mears, Maria N. B. Cajimat, Matthias J. Schnell   +4 more
doaj   +1 more source

Purification of Crimean–Congo hemorrhagic fever virus nucleoprotein and its utility for serological diagnosis

Scientific Reports, 2021
Crimean–Congo hemorrhagic fever virus (CCHFV) causes a zoonotic disease, Crimean–Congo hemorrhagic fever (CCHF) endemic in Africa, Asia, the Middle East, and Southeastern Europe.
Boniface Pongombo Lombe, Hiroko Miyamoto, Takeshi Saito, Reiko Yoshida, Rashid Manzoor, Masahiro Kajihara, Masayuki Shimojima, Shuetsu Fukushi, Shigeru Morikawa, Tomoki Yoshikawa, Takeshi Kurosu, Masayuki Saijo, Qing Tang, Justin Masumu, David Hawman, Heinz Feldmann, Ayato Takada   +16 more
doaj   +1 more source

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

Tropical Medicine and Infectious Disease, 2022
Crimean–Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960.
Moufid Mhamadi, Aminata Badji, Idrissa Dieng, Alioune Gaye, El Hadji Ndiaye, Mignane Ndiaye, Moundhir Mhamadi, Cheikh Talibouya Touré, Mouhamed Rassoul Mbaye, Mamadou Aliou Barry, Oumar Ndiaye, Babacar Faye, Fatimata Amadou Ba, Boly Diop, Mamadou Ndiaye, Mathioro Fall, Samba Niang Sagne, Gamou Fall, Cheikh Loucoubar, Hugues Fausther-Bovendo, Amadou Alpha Sall, Gary Kobinger, Ousmane Faye, Mawlouth Diallo, Oumar Faye   +24 more
doaj   +1 more source

NUCLEOSIDE-MODIFIED MRNA VACCINES PROTECT IFNAR -/- MICE AGAINST CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS INFECTION

International Journal of Infectious Diseases, 2023
Intro: Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV), is the causative agent of Crimean-Congo hemorrhagic fever (CCHF). Occurrence of the virus coincides with the distribution of its primary vector and reservoir, Hyalomma ticks.
A. Mirazimi
doaj   +1 more source

Construction and evaluation of DNA vaccine encoding Crimean Congo hemorrhagic fever virus nucleocapsid protein, glycoprotein N-terminal and C-terminal fused with LAMP1

Frontiers in Cellular and Infection Microbiology, 2023
Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe hemorrhagic fever in humans and is mainly transmitted by ticks. There is no effective vaccine for Crimean-Congo hemorrhagic fever (CCHF) at present.
Yong-Liang Hu, Yong-Liang Hu, Lian-Qing Zhang, Lian-Qing Zhang, Xiao-Qian Liu, Xiao-Qian Liu, Wei Ye, Yue-Xi Zhao, Yue-Xi Zhao, Liang Zhang, Zun-Xian Qiang, Lin-Xuan Zhang, Ying-Feng Lei, Dong-Bo Jiang, Lin-Feng Cheng, Fang-Lin Zhang   +15 more
doaj   +1 more source