Results 11 to 20 of about 4,301 (202)

The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey [PDF]

BMC Infectious Diseases, 2009
Background Crimean-Congo Hemorrhagic Fever (CCHF) is a fatal infection, but no clinical case due to AP92 strain was reported. We described the first clinical case due to AP92 like CCHFV.
Midilli Kenan, Gargılı Ayşen, Ergonul Onder, Elevli Murat, Ergin Sevgi, Turan Nesrin, Şengöz Gönül, Ozturk Recep, Bakar Mehmet   +8 more
doaj   +3 more sources

Geographical Variability Affects CCHFV Detection by RT–PCR: A Tool for In-Silico Evaluation of Molecular Assays [PDF]

Viruses, 2019
The Crimean−Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations.
Cesare E. M. Gruber, Barbara Bartolini, Concetta Castilletti, Ali Mirazimi, Roger Hewson, Iva Christova, Tatjana Avšič, Roland Grunow, Anna Papa, María P. Sánchez-Seco, Marion Koopmans, Giuseppe Ippolito, Maria R. Capobianchi, Chantal B. E. M. Reusken, Antonino Di Caro   +14 more
doaj   +9 more sources

The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells

Nature Communications
The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal hemorrhagic diseases in humans. CCHFV has a broad tropism and can infect a variety of species and tissues. Here,
Maureen Ritter, Lola Canus, Anupriya Gautam, Thomas Vallet, Li Zhong, Alexandre Lalande, Bertrand Boson, Apoorv Gandhi, Sergueï Bodoirat, Julien Burlaud-Gaillard, Natalia Freitas, Philippe Roingeard, John N. Barr, Vincent Lotteau, Vincent Legros, Cyrille Mathieu, François-Loïc Cosset, Solène Denolly   +17 more
doaj   +6 more sources

Host Community Traits Driving Crimean-Congo Hemorrhagic Fever Virus Maintenance in Iberian Ecosystems. [PDF]

Transbound Emerg Dis
Crimean‐Congo hemorrhagic fever (CCHF) is a tick‐borne zoonosis of significant public health concern, maintained in complex multihost systems shaped by ecological, climatic, and anthropogenic drivers. In the Iberian Peninsula, changing land‐use patterns and biodiversity loss may be reshaping host communities in ways that alter local transmission ...
Xavier P, Perelló A, Luque-Castro V, Relimpio D, Barroso P, Almeida V, de la Fuente J, Balseiro A, Ruiz-Fons F, Gortázar C.   +9 more
europepmc   +2 more sources

The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean–Congo Hemorrhagic Fever Virus (CCHFV)

Viruses
Crimean–Congo hemorrhagic fever virus (CCHFV) is an orthonairovirus from the Bunyavirales order that is widely distributed geographically and causes severe or fatal infections in humans.
Aysegul Pirincal, Mehmet Z. Doymaz
doaj   +3 more sources

Development and Characterization of Microsatellite Genetic Markers for <i>Hyalomma rufipes</i>, a Tick Vector of Crimean-Congo Hemorrhagic Fever Virus. [PDF]

Ecol Evol
This study developed and validated 14 polymorphic microsatellite markers to investigate the population genetics of Hyalomma rufipes, a tick species that transmits Crimean‐Congo Hemorrhagic Fever Virus (CCHFV) in East Africa. Ticks collected from livestock in northern Kenya were morphologically and genetically identified, followed by genome sequencing ...
Ahmad H, Aool W, Anyango V, Nakayaki TM, Mulwa F, Chelangat B, Lutwama JJ, Kayondo JK, Lukindu M, Mutisya J, Lutomiah J, Hensley LE, Cohnstaedt LW, Onyango MG, Brelsfoard CL.   +14 more
europepmc   +2 more sources

Crimean-Congo Hemorrhagic Fever Virus (CCHFV): A Silent but Widespread Threat [PDF]

Current Tropical Medicine Reports, 2021
Abstract Purpose of Review This review is aimed at highlighting recent research and articles on the complicated relationship between virus, vector, and host and how biosurveillance at each level informs disease spread and risk.
Paul A. Kuehnert, Christopher P. Stefan, Catherine V. Badger, Keersten M. Ricks   +3 more
openaire   +2 more sources

CCHFV vaccine development, current challenges, limitations, and future directions

Frontiers in Immunology, 2023
Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a
Büşra Ahata, Büşra Ahata, Günseli Bayram Akçapınar   +2 more
openaire   +3 more sources

Immunological Analysis of a CCHFV mRNA Vaccine Candidate in Mouse Models [PDF]

Vaccines, 2019
Development of new vaccine platforms against viral diseases is considered urgent. In recent years, mRNA constructs have attracted great interest in this field due to unique advantages over conventional gene transfer platforms. In the present study, we developed a new naked conventional mRNA vaccine expressing the non-optimized small (S) segment of the ...
Touraj Aligholipour Farzani, Katalin Földes, Koray Ergünay, Hakan Gurdal, Aliye Bastug, Aykut Ozkul   +5 more
openaire   +5 more sources

Mutational analysis of catalytic site domain of CCHFV L RNA segment

Journal of Molecular Modeling, 2023
Crimean-Congo haemorrhagic fever virus (CCHFV) has tripartite RNA genome and is endemic in various countries of Asia, Africa and Europe.The present study is focused on mutation profiling of CCHFV L segment and phylogenetic clustering of protein dataset into six CCHFV genotypes.Phylogenetic tree rooted with NCBI reference sequence (YP_325663.1 ...
Neha Kaushal, Manoj Baranwal
openaire   +2 more sources