Results 81 to 90 of about 2,525 (164)

Animal Exposure Model for Mapping Crimean-Congo Hemorrhagic Fever Virus Emergence Risk

Emerging Infectious Diseases
To estimate the determinants of spatial variation in Crimean-Congo hemorrhagic fever virus (CCHFV) transmission and to create a risk map as a preventive public health tool, we designed a survey of small domestic ruminants in Andalusia, Spain.
Sara Baz-Flores, Débora Jiménez-Martín, Alfonso Peralbo-Moreno, Cesar Herraiz, David Cano-Terriza, Raúl Cuadrado-Matías, Ignacio García-Bocanegra, Francisco Ruiz-Fons   +7 more
doaj   +1 more source

HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA

PLOS Neglected Tropical Diseases
Crimean-Congo Hemorrhagic Fever virus (CCHFV) is a tick-borne pathogen that causes severe acute fever disease in humans and requires a biosafety level 4 laboratory for handling. Hazara virus (HAZV), belonging to the same virus genus as CCHFV, does not exhibit pathogenesis in humans.
Moe Ikegawa, Norisuke Kano, Daisuke Ori, Mizuki Fukuta, Minato Hirano, Roger Hewson, Kentaro Yoshii, Taro Kawai, Takumi Kawasaki   +8 more
openaire   +2 more sources

Prevalence of crimean Congo hemorrhagic fever in Khyber Pakhtunkhwa, Pakistan

Travel Medicine and Infectious Disease
Background: CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented.
Asad Zia, Ali Talha Khalil, Naz Alam, Abdul Qadoos Khan, Mubarak Ali Khan, Yasar Yosafzai, Asif Ali, Ihsan Ullah, Ali Rehman Wazir   +8 more
doaj   +1 more source

Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks

Heliyon, 2017
Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne zoonotic disease caused by the CCHF virus (CCHFV). In this study, an experimental approach combining RT-PCR and proteomics was used for the identification and characterization of CCHFV in ...
Isabel G. Fernández de Mera, Ilias Chaligiannis, Angélica Hernández-Jarguín, Margarita Villar, Lourdes Mateos-Hernández, Anna Papa, Smaragda Sotiraki, Francisco Ruiz-Fons, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente   +10 more
doaj   +1 more source

Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

Nature Communications
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic disease with no
Shanna S. Leventhal, Thomas Bisom, Dean Clift, Deepashri Rao, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan A. Mihalakakos, Troy Hinkley, Steven J. Reynolds, Sonja M. Best, Jesse H. Erasmus, Leo C. James, Heinz Feldmann, David W. Hawman   +14 more
doaj   +1 more source

Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

Frontiers in Cellular and Infection Microbiology, 2017
Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%.
Anna Papa, Katerina Tsergouli, Katerina Tsioka, Ali Mirazimi, Ali Mirazimi, Ali Mirazimi   +5 more
doaj   +1 more source

Antibodies Targeting the CCHFV Nucleocapsid Protein Require TRIM21 for Protection

Abstract Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic disease and there are currently no widely approved or highly efficacious interventions available ...
David Hawman, Shanna Leventhal, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan Mihalakakos, Troy Hinkley, Jesse Erasmus, Heinz Feldmann   +8 more
openaire   +1 more source

The CD8+T cells response is sufficient for protection with a CCHFV M-segment based DNA vaccine and GP38 enhances vaccine immunogenicity

International Journal of Infectious Diseases
Introduction: Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widely distributed tick-borne virus of human medical importance, with outbreaks occurring in the Middle East, Asia, Africa, and parts of Western Europe. Our team developed and tested
Dr. Joseph Golden, Collin Fitzpatrick, Dr John Suschak, Tamara Clements, Dr. Keersten Ricks, Mariano Sanchez-Lockhart, Dr Aura Garrison   +6 more
doaj   +1 more source

Establishment of two serological methods for detecting IgG and neutralizing antibodies against Crimean-Congo hemorrhagic fever virus glycoprotein

Frontiers in Cellular and Infection Microbiology
IntroductionThe Crimean-Congo hemorrhagic fever virus (CCHFV), the most geographically widespread tick-borne virus, is endemic in Africa, Eastern Europe and Asia, with infection resulting in mortality in up to 30% of cases.
Qi Wang, Qi Wang, Shen Wang, Zhikang Shi, Zhengrong Li, Zhengrong Li, Yongkun Zhao, Na Feng, Tiecheng Wang, Feihu Yan, Xianzhu Xia, Xianzhu Xia   +11 more
doaj   +1 more source

Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus.

PLoS Pathogens
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus, prevalent in more than 30 countries worldwide. Human infection by this virus leads to severe illness, with an average case fatality of 40%.
Liushuai Li, Tingting Chong, Lu Peng, Yajie Liu, Guibo Rao, Yan Fu, Yanni Shu, Jiamei Shen, Qinghong Xiao, Jia Liu, Jiang Li, Fei Deng, Bing Yan, Zhihong Hu, Sheng Cao, Manli Wang   +15 more
doaj   +1 more source