Results 151 to 160 of about 138,616 (334)

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis

Cell Communication and Signaling
Background Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation.
Yue Dong, Ying Dong, Chengyue Zhu, Lan Yang, Hanlin Wang, Junqing Li, Zixuan Zheng, Hanwei Zhao, Wanji Xie, Meiting Chen, Zhijun Jie, Jia Li, Yi Zang, Jindong Shi   +13 more
doaj   +1 more source

Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers [PDF]

, 2014
François Moisan, E. Brian Francisco, Anamaria Brozović, George E. Durán, Yan C. Wang, Shalini Chaturvedi, Shobha Seetharam, Linda A. Snyder, Parul Doshi, Branimir I. Šikić   +9 more
openalex   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy. [PDF]

, 2018
BACKGROUND:The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to ...
Ashwood, Paul, Croen, Lisa A, DeLorenze, Gerald N, Heuer, Luke S, Jones, Karen L, Kharrazi, Martin, Traglia, Michela, Van de Water, Judy, Weiss, Lauren A, Yolken, Robert   +9 more
core  

Abstract 123: Ccl2-ccr2 Signaling Is Critical To Macrophage Recruitment, Angiogenesis, And Regeneration Across Nerve Autograft Alternatives

, 2020
Matthew D. Wood, Deng Pan, Lauren Schellhardt, Anja Fuchs, Alison K. Snyder‐Warwick, Susan E. Mackinnon   +5 more
openalex   +1 more source

DNA Vaccination with CCL2 DNA Modified by the Addition of an Adjuvant Epitope Protects against “Nonimmune” Toxic Renal Injury [PDF]

, 2006
Guoping Zheng, Yiping Wang, Shi-Hua Xiang, Yuet-Ching Tay, Huiling Wu, Debbie Watson, Jason D. Coombes, Gopala K. Rangan, Stephen I. Alexander, David C.H. Harris   +9 more
openalex   +1 more source

MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4′-methylene diphenyl diisocyanate exposed macrophages

, 2021
Chen‐Chung Lin, Brandon F. Law, Justin M. Hettick   +2 more
openalex   +2 more sources

STEM-30. NECROPTOTIC ASTROCYTES CONTRIBUTE TO MAINTAINING STEMNESS OF DISSEMINATED MEDULLOBLASTOMA THROUGH CCL2 SECRETION [PDF]

, 2020
Hailong Liu, Youliang Sun, Janusz Franco‐Barraza, Z John Wang, Xinguang Yu, Shiyu Feng   +5 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source