Results 141 to 150 of about 100,458 (303)

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis

Cell Communication and Signaling
Background Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation.
Yue Dong, Ying Dong, Chengyue Zhu, Lan Yang, Hanlin Wang, Junqing Li, Zixuan Zheng, Hanwei Zhao, Wanji Xie, Meiting Chen, Zhijun Jie, Jia Li, Yi Zang, Jindong Shi   +13 more
doaj   +1 more source

CCL2 augments T. cruzi TEM.

, 2013
(A) To assess the effect of the chemokine CCL2 on TEM, EC monolayers were pre-incubated with CCL2 for 1 hour before the start of the standard TEM assay.
David M. Engman (357296), Cheryl L. Olson (491498), Bria M. Coates (491494), Ming Y. Makanji (491496), Conrad L. Epting (357294), David P. Sullivan (491495), Nga Y. Du (491497), William A. Muller (267832)   +7 more
core   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

GMF induces CCL2 release from mouse primary mast cells.

, 2015
In dose-response and time-course studies, BMMCs were incubated with GMF and assayed CCL2 level in the culture supernatant media by ELISA (n = 4). (A) GMF significantly induced CCL2 release from BMMCs-derived from wild type mice.
Mark K. Santillan (783787), Evert Yang (783783), Smita Zaheer (783785), Asgar Zaheer (783788), Duraisamy Kempuraj (83338), Ramasamy Thangavel (783782), Donna A. Santillan (783786), Sagar Pattani (783784)   +7 more
core   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Biomaterial Surface-Mediated Macrophages Exert Immunomodulatory Roles by Exosomal CCL2-Induced Membrane Integrin β1 Trafficking in Recipient Cells

The interaction between biomaterials and immune system is a critical area of research, especially in tissue engineering and regenerative medicine. A fascinating and less explored aspect involves the immunomodulatory behaviors of macrophage (MΦ)-derived ...
Yonghua Sun, Xing Wang, Yong Han, Ruiqiang Hang, Sun, Yonghua, Zhao, Yuyu, Xiaobo Huang, Di Huang, Han, Yong, Wang, Huaiyu, Zhang, Xiangyu, Hang, Ruiqiang, Yuyu Zhao, Huaiyu Wang, Li, Huifei, Yao, Xiaohong, Ruiyue Hang, Xiao, Yin, Hang, Ruiyue, Huang, Xiaobo, Wang, Xing, Yao, Runhua, Huifei Li, Runhua Yao, Yin Xiao, Xiaohong Yao, Huang, Di, Xiangyu Zhang   +27 more
core   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype

eLife
CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis.
Feroz Akhtar, Joselin Hernandez Ruiz, Ya-Guang Liu, Roy G Resendez, Denis Feliers, Liza D Morales, Alvaro Diaz-Badillo, Donna M Lehman, Rector Arya, Juan Carlos Lopez Alvarenga, John Blangero, Ravindranath Duggirala, Srinivas Mummidi   +12 more
doaj   +1 more source