Results 131 to 140 of about 4,498 (153)

Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26

Human Reproduction, 2013
What are the effects of the eotaxin group of chemokines (CCL11, CCL24 and CCL26) on extravillous trophoblast (EVT) functions important during uterine decidual vessel remodelling?CCL11, CCL24 and CCL26 can regulate EVT migration, invasion and adhesion, highlighting a potential regulatory role for these chemokines during uterine decidual spiral arteriole
CHAU, SIMON, MURTHI, PADMA, Wong, May, Whitley, Guy StJ, BRENNECKE, SHAUN, KEOGH, ROSEMARY   +5 more
openaire   +2 more sources

Abstract P3066: Macrophage-derived Ccl24 Worsens Cardiac Dysfunction Following Pressure-overload

Circulation Research, 2022
Heart failure (HF) is the leading cause of death worldwide. Systemic inflammation is associated with HF and is considered an independent predictor of adverse cardiac outcomes. Macrophages are the most abundant immune cells in the heart and have integral roles in cardiac homeostasis and remodeling. Despite their unique identity and homeostatic functions,
Preethy Parthiban, Fanta Barrow, Dogacan Yucel, Richard Gonigam, Adam Herman, Hailey Rhoades, Maya Demirchian, Haiguang Wang, Jop H Van Berlo, Xavier Revelo   +9 more
openaire   +1 more source

CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment

Rheumatology, 2022
Abstract Objective Oligoarticular JIA disease progression and outcomes are variable. Our objective is to detect protein markers that would allow for earlier intervention to potentially halt disease progression.
Lina Al-Jaberi, Megan M Simonds, Anne Marie C Brescia   +2 more
openaire   +2 more sources

All Eotaxins CCL11, CCL24 and CCL26 are Increased but to Various Extents in Pulmonary Tuberculosis Patients

Clinical Laboratory, 2014
Mycobacterium tuberculosis is a pulmonary pathogen responsible for tuberculosis. Tuberculosis (TB) is characterized histologically by granulomas at the site of disease activity. Primary pathologic feature of TB is formation of a granuloma, and chemokines are known to play an important role in the formation of granulomas during infection. Therefore, the
Abumoslem Rashidi, Sharifabadi, Gholamhossein, Hassanshahi, Seyed Razi, Ghalebi, Mohammad Kazemi, Arababadi, Hossein, Khorramdelazad, Nahid, Zainodini, Ziba, Shabani   +6 more
openaire   +2 more sources

Microarray Analysis Reveals CCL24/Eotaxin-2 as an Effector of the Pathogenetic Effects Induced by HIV-1 Nef

Current Drug Discovery Technologies, 2007
Human immunodeficiency virus (HIV)-1 Nef is a regulatory protein critically involved in AIDS pathogenesis. We previously demonstrated that extracellular Nef is efficiently internalized by human primary monocyte-derived macrophages (MDMs), thereby activating a number of transcription factors including STATs, MAPKs, IRF-3, and NF-kappaB.
Gianna Fiorucci, Eleonora Olivetta, Maria Vincenza Chiantore, Maurizio Federico   +3 more
openaire   +4 more sources

Machine Learning Identifies Key Proteins in Primary Sclerosing Cholangitis Progression and Links High CCL24 to Cirrhosis

International Journal of Molecular Sciences
Primary sclerosing cholangitis (PSC) is a rare, progressive disease, characterized by inflammation and fibrosis of the bile ducts, lacking reliable prognostic biomarkers for disease activity. Machine learning applied to broad proteomic profiling of sera allowed for the discovery of markers of disease presence, severity, and cirrhosis and the ...
Francesca Saffioti, Douglas Thorburn
exaly   +3 more sources

The chemokines CCL11, CCL20, CCL21, and CCL24 are preferentially expressed in polarized human secondary lymphoid follicles

The Journal of Pathology, 2004
AbstractChemokines regulate cellular trafficking to and from lymphoid follicles. Here, the distribution pattern of four CCL chemokines is defined by in situ hybridization in human lymphoid follicles from tonsils and lymph nodes (LNs) of newborns and adults. Cells expressing CCL11 (eotaxin) and CCL20 (Exodus) were preferentially located within follicles,
Buri, Caroline, Gutersohn, Andreas, Hauser, Chantal, Kappeler, Andreas, Müller, Christoph   +4 more
openaire   +4 more sources

Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts

Annals of Allergy, Asthma and Immunology, 2010
Eotaxin-2/CCL24 and eotaxin-3/CCL26 play an important role in eosinophil chemotaxis and activation in asthma. We previously demonstrated that eotaxin/CCL11 is profibrogenic for human lung fibroblasts. The effect of eotaxin-2/ CCL24 and eotaxin-3/CCL26 on lung fibroblasts has not yet been investigated.To evaluate whether eotaxin-2/CCL24 and eotaxin-3 ...
Ilaria Puxeddu, Francesca Levi-Schaffer, Reuven Reich   +2 more
exaly   +5 more sources

Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure

ABSTRACT Inflammation is a significant risk factor and contributes to cardiovascular disease by driving both adaptive and maladaptive processes. Macrophages are the most abundant immune cells in the heart and play an important role in the remodeling of cardiac tissue.
Preethy Parthiban, Fanta Barrow, Huy Nguyen, Fernando Neto, Kira Florczak, Haiguang Wang, Dogacan Yucel, Hong Liu, Micah Draxler, Erin Ciske, Gavin Fredrickson, Adam Herman, Marc E. Rothenberg, Samuel Dudley, Jop van Berlo, Xavier S. Revelo   +15 more
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Serum proteomics reveals association of CCL24 with key aspects of primary sclerosing cholangitis

Journal of Hepatology, 2023
Raanan Greenman, Tom Snir, Avi Katav, Omer Levi, Revital Aricha, John Lawler, Douglas Thorburn, Massimo Pinzani, Ilan Vaknin   +8 more
openaire   +1 more source