Results 101 to 110 of about 39,533 (201)

Reduced liver fibrosis in CCL3^−/− mice after CCl₄ challenge.

, 2013
Acute liver injury after CCl4 challenge is associated with augmented hepatic expression of CCL3, while CCL3 after chronic CCl4 treatment has a tendency toward higher expression (A).
David Scholten (276343), Hermann E. Wasmuth (323874), Daniel Heinrichs (323862), Christian Trautwein (64353), Petra Fischer (422605), Hacer Sahin (323867), Andreas Nellen (323859), Marie-Luise Berres (323865)   +7 more
core   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Topical CCL3 Is Well-Tolerated and Improves Liver Function in Diabetic Mice: Evidence from a 14-Day Toxicity Study

Cells
Diabetic wounds exhibit impaired immune function, delayed neutrophils recruitment, and heightened infection risk which compromises early infection control and delays healing.
Deepa Dehari, Rajalekshmy Padmakumari, Getnet Tesfaw, Fernando A. Fierro, Guillermo A. Ameer, Sasha H. Shafikhani   +5 more
doaj   +1 more source

Cellular senescence and chemokine signaling in liver regeneration: insights from single-cell RNA sequencing

European Journal of Medical Research
Liver regeneration following partial hepatectomy (PHx) is a complex process. While cellular senescence and chemokine signaling have been implicated in tissue repair, their cell type–specific roles in liver regeneration remain poorly understood.
Zhipeng Bao, Longfu Xi, Xiaoyue Han, Guangpeng Jia, Peng Wang, Shi Wang, Saqirilatu, Xiaodong Wang   +7 more
doaj   +1 more source

Liver fibrosis in CCL3^−/− mice after eight weeks of MCD diet.

, 2013
CCL3 expression is increased in MCD-fed wild-type mice compared to untreated control (A). Representative Sirius red staining of CCL3−/− and wild-type (CCL3+/+) mice after MCD diet (x100 magnification).
David Scholten (276343), Hermann E. Wasmuth (323874), Daniel Heinrichs (323862), Christian Trautwein (64353), Petra Fischer (422605), Hacer Sahin (323867), Andreas Nellen (323859), Marie-Luise Berres (323865)   +7 more
core   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Sensor‐Detected Hypoglycaemia Is Associated With Inflammatory Protein and Immune Cell Alterations in People With Diabetes: Findings From the Hypo‐METRICS Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Experimental hypoglycaemia induces a persistent inflammatory response. We investigated whether real‐life sensor‐detected hypoglycaemia (SDH) is associated with immune parameters in people with Type 1 and Type 2 diabetes and explored potential differences between the groups.
Mandala Ajie, Namam Ali, Marijn S. Hendriksz, Patrick Divilly, Marloes J. Rietveld, Evertine J. Abbink, Pratik Choudhary, Julie Maria Bøggild Brøsen, Ulrik Pedersen‐Bjergaard, Rory J. McCrimmon, Mark Evans, Julia K. Mader, Bastiaan E. de Galan, Rinke Stienstra, Cees J. Tack, on behalf of the Hypo‐RESOLVE Consortium   +15 more
wiley   +1 more source

Exploring CCL3 as a potential prognostic marker in Merkel cell carcinoma

, 2020
Merkel cell carcinoma (MCC) is a rare, neuroendocrine carcinoma of the skin that is known to have poor prognosis. It is associated with the Merkel cell polyomavirus (MCPyV) and majority of cases harbor this infection. Other risk factors include older age,
Jagdeo, Joanna
core  

Cytotoxicity of CCL3 and CCL28 on human cells.

, 2013
Absorbance of haemoglobin release from erythrocytes following exposure to CCL3 and CCL28 is expressed as percent of positive control, 2% Triton X-100 (5A). Cytotoxicity on HaCaT keratinocytes were measured by cell-permeabilizing effects of CCL3 and CCL28
Matthias Mörgelin (109607), Paul Bates (134046), Mattias Collin (62685), Arne Egesten (365606), Oonagh Shannon (194608), Sara K. Söbirk (393666)   +5 more
core   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source