Results 91 to 100 of about 39,533 (201)

Zwiększone stężenie chemokiny CCL3/MIP-1 alfa w ciężkiej astmie oskrzelowej [PDF]

, 2011
Introduction. Bronchial asthma is a chronic inflammatory disease with the dominant role of type 2 T helper cells. In some asthma phenotypes, particularly in severe bronchial asthma, type 1 T helper cells may participate.
Rogala, Barbara, Rymarczyk, Barbara, Glück, Joanna   +2 more
core   +1 more source

Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression [PDF]

, 2006
We previously observed that a chemokine, macrophage inflammatory protein-1 α/CCL3, and its receptor, CCR1, were aberrantly expressed in human hepatocellular carcinoma (HCC) tissues.
49, Nakamoto, Yasunari, Lu, Peirong, Mukaida, Naofumi, 60185923, Yang, Xiaoqin, 30182067, Murphy, Philip M., 40293352, Gao, Ji Liang, 47496, 108, 47497, 47494, 47495, Fujii, Chifumi, 17028, 62, Kaneko, Shuichi, 10361982   +19 more
core   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages

Journal of Pharmacological Sciences, 2015
The anti-inflammatory properties of TC-2559, an α4β2 nicotinic acetylcholine receptor (nAChR) agonist, on cultured murine macrophages was investigated.
Norikazu Kiguchi, Fumihiro Saika, Yuka Kobayashi, Mei-Chuan Ko, Shiroh Kishioka   +4 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Regulatory B cell CCL3 competency promotes disease resolution and oligodendrogenesis in experimental autoimmune encephalomyelitis

Communications Biology
Regulatory B cells (Bregs) contribute to immune homeostasis via IL-10–dependent and independent pathways. To dissect additional mediators, we investigated splenic derived GM-CSF/IL-15 fusokine (GIFT15)-induced Bregs in experimental autoimmune ...
Andrea Pennati, Xingyi Tang, Catigan Hedican, Amar Yeware, Md Mahfuzur Rahman, Owen A. Zeitler, Shala Yuan, Jacques Galipeau   +7 more
doaj   +1 more source

Diagnostic value of ultrasound combined with serum CCL3 and P-selectin for postoperative lower extremity deep vein thrombosis in patients with hip fractures

Zhongguo linchuang yanjiu
Objective： To investigate the value of color Doppler ultrasound combined with serum chemokine C-C motif ligand 3(CCL3) and P-selectin levels for the diagnosis of postoperative lower extremity deep vein thrombosis(LEDVT) in patients with hip fractures ...
YUAN Bo, DONG Hongna, LI Yali, YANG Wenbin, RAN Chao
doaj   +1 more source

Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine

Frontiers in Immunology, 2018
Current investigations underline the important roles of C–C motif ligands in the development of neuropathic pain; however, their participation in diabetic neuropathy is still undefined.
Ewelina Rojewska, Magdalena Zychowska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika   +5 more
doaj   +1 more source

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source