Results 71 to 80 of about 39,533 (201)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer
Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide, especially in advanced stages where limited treatment options result in poor prognosis.
Min Yang, Wei Wang, Wei Li, Yanan Li, Juan Zhang, Pengfei Rong, Di Wu, Qi Liang, Yao Deng, Xiaoqian Ma, Lu Cao, Muqi Liu, Linzhe Li, Xingshi Gu, Cejun Yang, Huaping Liu   +15 more
doaj   +1 more source

Alveolar macrophages lack CCR2 expression and do not migrate to CCL2

Journal of Inflammation, 2007
Background The recruitment of mononuclear cells has important implications for tissue inflammation. Previous studies demonstrated enhanced CCR1 and CCR5 expression and decreased CCR2 expression during in vitro monocyte to macrophage differentiation.
Hunter Melissa G, Lobb Jennifer M, Ali Naeem A, Opalek Judy M, Marsh Clay B   +4 more
doaj   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice [PDF]

, 2014
Patients with inflammatory bowel diseases often develop colon carcinoma. Combined treatment of azoxymethane (AOM) and dextran sulfate sodium (DSS) recapitulates colitis-associated cancer in mice.
47856, 47857, 49, Shinagawa, Kei, Mukaida, Naofumi, 47848, Matsushima, Kouji, 30182067, Baba, Tomohisa, Sasaki, Soichiro, 457, 00452095, 50583473   +12 more
core   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma

, 2013
[[abstract]]Chemokine (C-C motif) ligand 3 (CCL3), also known as macrophage inflammatory protein-1alpha, is a cytokine involved in inflammation and activation of polymorphonuclear leukocytes.
Chin-Jung Hsu;Min-Huan Wu;Chin-Yuan Chen;Chun-Hao Tsai;Horng-Chaung Hsu;Chih-Hsin Tang
core  

CCL3 promotes germinal center B cells sampling by follicular regulatory T cells

, 2018
Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity ...
Rita Wu, Michael I. Ivanitskiy, Matangi Marthi, Irina L. Grigorova, Zachary L. Benet, Jahan B. Gabayre, Sahil S. Sethi, Jackson S. Turner   +7 more
core   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages

Cell Division
Background Multiple myeloma (MM) is a malignancy where drug resistance often leads to relapse or refractory disease. Chemokine receptor 5 (CCR5) has emerged as a novel therapeutic target.
Huiye Yang, Yuchan He, Fujun Qu, Jie Zhu, Liyuan Deng, Fang Jiang, Xianyi Wu, Yixuan Chen, Ali Kashif, Xiaotao Wang   +9 more
doaj   +1 more source