Results 81 to 90 of about 39,533 (201)

Otitis Media and Nasopharyngeal Colonization in ccl3 ^−/− Mice

, 2017
We previously found CC chemokine ligand 3 (CCL3) to be a potent effector of inflammation during otitis media (OM): exogenous CCL3 rescues the OM phenotype of tumor necrosis factor-deficient mice and the function of macrophages deficient in several innate
Allen F. Ryan, Arwa Kurabi, Dominik Deniffel, Brian Nuyen, Keigo Suzukawa, Jun Hung, Kwang Pak, Stephen I. Wasserman   +7 more
core   +1 more source

Evaluation of plasma CCL3 levels in individuals with newly diagnosed chronic lymphocytic leukemia and it’s correlation with clinical and laboratory parameters

Iraqi Journal of Hematology
BACKGROUND: The most prevalent type of leukemia in adults is called chronic lymphocytic leukemia (CLL). is a lymphoproliferative condition is defined by the mature clone’s expansion in blood, secondary lymphoid tissues, spleen and the bone marrow.
Ruaa Hameed Nasif, Maysem Mouayad Abd Al-Mahdi   +1 more
doaj   +1 more source

Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide [PDF]

, 2010
Background Chemokines are emerging as important mediators of CNS inflammation capable of activating leukocyte integrins and directing the migration of leukocyte subsets to sites of antigenic challenge.
Ray Chui, Chui Ray, Katerina Dorovini-Zis, Chui, Ray, Dorovini-Zis Katerina, Dorovini-Zis, Katerina   +5 more
core   +1 more source

Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation

, 2013
Objective-Despite common disbelief that neutrophils are involved in atherosclerosis, evidence is accumulating for a causal role of neutrophils in atherosclerosis. CC chemokine ligand (CCL)3 is an inflammatory chemokine and its expression is significantly
Kuiper, Johan, Theo J.C. van Berkel, Johan Kuiper, Bot, Martine, Erik A.L. Biessen, Peter J. van Santbrink, van Berkel, Theo J. C., Adriaan O. Kraaijeveld, Martine Bot, Ilze Bot, Santbrink, P.J. van, Biessen, Erik A. L., Biessen, E.A.L., Suzanne J.A. Korporaal, Bot, I., Bot, Ilze, Jager, S.C.A. de, Bot, M., Kuiper, J., van Santbrink, Peter J., Korporaal, S.J.A., Saskia C.A. de Jager, Kraaijeveld, A.O., Biessen, Erik A. L.; id_orcid, de Jager, Saskia C. A., Kraaijeveld, Adriaan O., Berkel, T.J.C. van, Korporaal, Suzanne J. A.   +27 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Tocilizumab for severe and refractory mucous membrane pemphigoid. [PDF]

J Eur Acad Dermatol Venereol
Elevated IL‐6 levels identified in mucous membrane pemphigoid support IL‐6 blockade, with tocilizumab demonstrating clinical benefit in nine patients with severe and refractory mucous membrane pemphigoid. Abstract Background Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease involving mucous membranes with a potentially ...
Tedbirt B, Maho-Vaillant M, Gueudry J, Golinski ML, Marcaillou M, Bergeret B, Chambon G, Bouchetemble P, Bekri S, Tebani A, Maillard H, Morice C, Vautier A, Libert EP, Le Roux-Villet C, Carrette M, Boyer O, Hébert V, Calbo S, Gillibert A, Joly P.   +20 more
europepmc   +2 more sources

Ginsenoside Rg1 Ameliorates LPS‐Induced Sepsis‐Associated Lung Injury in Mice via VEGFC/D‐VEGFR3 Signaling‐Mediated Lymphangiogenesis and Lymphatic Remodeling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
He Wang, Lan Hu, Chun‐Pan Zhang, Wen‐Jie Qi, Yu‐Guo Song   +4 more
wiley   +1 more source

Zinc Finger Protein Tristetraprolin Interacts with CCL3 mRNA and Regulates Tissue Inflammation

, 2011
Zinc finger protein tristetraprolin (TTP) modulates macrophage inflammatory activity by destabilizing cytokine mRNAs. In this study, through a screen of TTP-bound mRNAs in activated human macrophages, we have identified CCL3 mRNA as the most abundantly ...
Jaeyul Kwon, Ping-yuan Wang, Alan T. Remaley, Marcelo J. Amar, Paul M. Hwang, Perry J. Blackshear, Ju-Gyeong Kang   +6 more
core   +1 more source

Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran, Zaharadeen Jimoh, Tariq Issa, Nahla A. Gomaa   +3 more
wiley   +1 more source