Results 61 to 70 of about 39,533 (201)

Plasma C-C Chemokine Concentrations in Intermediate Age-Related Macular Degeneration

Frontiers in Medicine, 2021
Purpose: To determine the relationship between plasma concentrations of the C-C chemokines CCL2, CCL3, CCL4, and CCL5 and intermediate age-related macular degeneration (iAMD) patients compared with control inidividuals to further define the inflammatory ...
Alan G. Palestine, Brandie D. Wagner, Brandie D. Wagner, Jennifer L. Patnaik, Rebecca Baldermann, Marc T. Mathias, Naresh Mandava, Anne M. Lynch   +7 more
doaj   +1 more source

CCL3 Production by Microglial Cells Modulates Disease Severity in Murine Models of Retinal Degeneration [PDF]

, 2014
Many degenerative retinal diseases illustrate retinal inflammatory changes that include infiltration of microglia and macrophages into the subretinal space.
Pearlman, Eric, Perusek, Lindsay, Maeda, Akiko, Maeda, Tadao, Kohno, Hideo   +4 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

High-pressure studies of radical-solvent molecule interactions in the CCl3 and bromine combination reactions of CCl3

, 2004
The combination reactions CCl3 + CCl3 (+ M) --> C2Cl6 (+ M) and CCl3 + Br (+ M) --> CCl3Br (+ M) (with rate constants of k(1) and k(2), respectively) were studied at temperatures of 250 and 300 K over the pressure range of 0.01-1000 bar.
Oum, K., Luther, L., Troe, Juergen
core   +1 more source

Recombinant Bacteroides fragilis enterotoxin-1 (rBFT-1) promotes proliferation of colorectal cancer via CCL3-related molecular pathways

Open Life Sciences, 2021
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and stands among the leading causes of cancer-related deaths. Although deregulation of the microbiota in the gastrointestinal tract has been frequently described in CRC ...
Xie Xiaoliang, Jiang Dan, Zhou Xuebing, Ye Xiaoping, Yang Ping, He Yaqin   +5 more
doaj   +1 more source

CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia

, 2011
B-cell receptor (BCR) signaling has been inferred as an important mechanism for disease progression in chronic lymphocytic leukemia (CLL) and other B-cell malignancies.
Hagop Kantarjian, Susan Lerner, Elena Hartmann, Diana Krupnik, William G. Wierda, Lillian Werner, Ruth LaPushin, Michael J. Keating, Andreas Rosenwald, Susan O'Brien, Lianchun Xiao, Donna Neuberg, Xuelin Huang, Thomas J. Kipps, Jan A. Burger, Mariela Sivina, Laura Rassenti   +16 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Risk indexes for draft CCL3 chemicals [PDF]

, 2009
To supplement the processes used for developing the draft third Contaminant Candidate List (CCL3) and better inform decisions made by the US Environmental Protection Agency on future CCLs, the authors offer an evaluation tool for efficiently synthesizing,
Rosen, Jeffrey S., J. Alan Roberson, Lueders, Matthew, Jeffrey S. Rosen, Matthew Lueders, Adams, Craig, Craig Adams, Roberson, J. Alan   +7 more
core   +1 more source