Results 211 to 220 of about 95,656 (302)

Sex-Specific Downregulation of CDK5RAP3 Exacerbates ER Stress-Mediated Inflammation and Apoptosis in CCl₄-Induced Acute Liver Injury. [PDF]

Genes (Basel)
Ruan J, Dong Q, Xu F, Jin Y, Yang Y, Li J, Cai Y.   +6 more
europepmc   +1 more source

Can disulfiram modulate liver injury in CCl4-induced fibrosis in rats? [PDF]

Gastroenterol Hepatol Bed Bench
Rostami A, Golchoobian R, Esmaeili Z, Asghari MH, Hafezi N, Babazadeh Z.   +5 more
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, Volume 13, Issue 26, 8 May 2026.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Inflammatory and resolution stages of hepatic injury: imaging with USPIO-enhanced MRI in mice. [PDF]

Eur Radiol Exp
Piraquive Agudelo J, Doblas S, Peoc'h K, Doan BT, Garteiser P, Van Beers BE.   +5 more
europepmc   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, Volume 13, Issue 26, 8 May 2026.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Targeted blockade of extracellular vesicles-mediated profibrotic vicious circle using EVs-based dual-drug delivery system to prevent liver fibrosis. [PDF]

J Nanobiotechnology
Sun J, Shen Y, Wang X, Men R, Xing X, Lv L, Yang F, Shen M, Zheng Y, Fan X, Liu J, Yang L.   +11 more
europepmc   +1 more source

GPND‐AI NULISA: A 15‐Protein AI classifier for diagnosis and co‐pathology profiling across neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Accurate clinical diagnosis of neurodegenerative diseases remains challenging, particularly when individuals have mixed pathologies. We implemented the generalizable protein‐based neurodegenerative disease artificial intelligence (GPND‐AI) classifier using the NUcleic acid‐Linked Immuno‐Sandwich Assay (NULISA) central nervous ...
Ying Xu, Marisa N Denkinger, Menghan Liu, Katherine Gong, Yike Chen, Daniel Western, Jigyasha Timsina, Yuchen Cheng, Yunchang Xie, Rui Mu, John Budde, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Alpana Singh, Isabel Alfradique‐Dunham, Tammie L. S. Benzinger, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Joel S. Perlumtter, B Joy Snider, Meghan C. Campbell, Paul T. Kotzbauer, Nicholas J. Ashton, Carlos Cruchaga   +25 more
wiley   +1 more source

The Spleen Promotes Liver Sinusoidal Endothelial Cell Angiogenesis by Stimulating the TGFβ/Smad2/3 Pathway Through GDF15. [PDF]

J Gastroenterol Hepatol
Deng X, Huang N, Du K, Zhang H, Du Z, Fan Y, Zhu M, Liu P, Mu Y, Li Z.   +9 more
europepmc   +1 more source

Systemic immune dysregulation in patients experiencing urogynaecological mesh failure

BJUI Compass, Volume 7, Issue 5, May 2026.
Abstract Objectives This study aimed to investigate the systemic immune landscape in patients experiencing urogynaecological mesh failure. The use of urogynaecological mesh was paused in the UK following an independent safety review that found ~1 in 15 women required removal due to complications. However, the mechanisms underpinning mesh failure remain
Shannon Jamieson, Cameron R. Dougan, Eloise Rennie, Patrick Card, Sudarshan Nallappa, Karen Smith, David J. Deehan, Karen Brown, Catharien M. U. Hilkens, Christopher Harding   +9 more
wiley   +1 more source