Results 151 to 160 of about 1,951 (186)

Convergence of coronary artery disease genes onto endothelial cell programs. [PDF]

Nature
Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM.   +26 more
europepmc   +1 more source

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome. [PDF]

Int J Mol Sci
Meecham A, McCurdy S, Frias-Anaya E, Li W, Gallego-Gutierrez H, Nguyen P, Li YS, Chien S, Shyy JY, Ginsberg MH, Lopez-Ramirez MA.   +10 more
europepmc   +1 more source

Cavernous malformations of the optic nerve and chiasm: illustrative case. [PDF]

J Neurosurg Case Lessons
Zhao X, Ho J, Nguyen V, Tavakol SA, Dunn IF.   +4 more
europepmc   +1 more source

Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol. [PDF]

Int J Oncol
Chen Y, Zhang Y, Yang H, Liu Q, Sui R, Shi J, Liang H, Liu J, Xu H, Piao H.   +9 more
europepmc   +1 more source

Expression of CCM2 and CCM3 during mouse gonadogenesis [PDF]

Journal of Assisted Reproduction and Genetics, 2015
Three cerebral cavernous malformation (CCM) proteins, CCM1, CCM2, and CCM3, regulate cell-cell adhesion, cell shape and polarity, and most likely cell adhesion to extracellular matrix. Recently, CCM2 and CCM3 are known to be expressed in control and varicocele-induced rat testes, but little is known about these proteins during gonadogenesis.
Aylin Yaba, Nazli Ece Gungor-Ordueri, Gamze Tanriover   +2 more
exaly   +6 more sources

Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

Human Mutation, 2008
Cerebral cavernous malformations (CCM) are prevalent cerebrovascular lesions predisposing to chronic headaches, epilepsy, and hemorrhagic stroke. Using a combination of direct sequencing and MLPA analyses, we identified 15 novel and eight previously published CCM1 (KRIT1), CCM2, and CCM3 (PDCD10) mutations.
Oǧuzkan Surucu, Ekkehard Kunze, Christian Netzer   +2 more
exaly   +5 more sources

Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C‐terminus

FEBS Letters, 2013
Cerebral cavernous malformations (CCM) are neurovascular dysplasias affecting up to 0.5% of the population. Mutations in the CCM2 gene are associated with acquisition of CCM.
Oriana S Fisher, James W Murphy, Börries Demeler   +2 more
exaly   +2 more sources

A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation [PDF]

Neurology and Clinical Neuroscience, 2022
Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation.
Emi Nomura, Yoshio Omote, Nozomi Hishikawa   +2 more
exaly   +2 more sources

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CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

Neurogenetics, 2007
Individuals carrying a mutation in one of the three cerebral cavernous malformation genes (CCM1/KRIT1, CCM2, CCM3) cannot be clinically distinguished, raising the possibility that they act within common molecular pathways. In this study, we demonstrate that CCM3 (PDCD10) coprecipitates and colocalizes with CCM2. We also show that CCM3 directly binds to
Thomas D Mueller, Ute Felbor
exaly   +3 more sources