Results 161 to 170 of about 1,951 (186)

CCM2 expression during prenatal development and adult human neocortex

International Journal of Developmental Neuroscience, 2011
AbstractCerebral cavernous malformation (CCM) is one of the most common types of vascular malformations of the central nervous system, affecting nearly one in 200 people. CCM lesions are characterized by grossly dilated vascular channels lined by a single layer of endothelium.
Gamze Tanriover, Berna Sozen, Murat Gunel   +2 more
exaly   +3 more sources

No CCM2 mutations in a cohort of 31 sporadic cases

Neurology, 2004
Cerebral cavernous malformation (CCM; MIM 116860) is a common disorder that is found in 0.1 to 0.5% of the population and represents ∼10 to 20% of cerebral vascular lesions.1 However, symptomatic disease is considerably less common. The lesions, which affect the brain vasculature, are characterized by abnormally enlarged capillary cavities in the brain
D J, Verlaan, S B, Laurent, G A, Rouleau, A M, Siegel   +3 more
openaire   +2 more sources

CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation [PDF]

Journal of Cell Biology, 2015
Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other neurological disorders.
Oriana S Fisher, Giulia Villari, Titus J Boggon   +2 more
exaly   +3 more sources

NCAR CCM2 simulation of the modern Antarctic climate

Journal of Geophysical Research: Atmospheres, 1994
The National Center for Atmospheric Research community climate model version 2 (CCM2) simulation of the circumpolar trough, surface air temperature, the polar vortex, cloudiness, winds, and atmospheric moisture and energy budgets are examined to validate the model's representation of the present‐day Antarctic climate. The results show that the CCM2 can
Ren‐Yow Tzeng, David H. Bromwich, Thomas R. Parish, Biao Chen   +3 more
openaire   +1 more source

User's Guide to NCAR CCM2

1992
This User's Guide describes the overall design of the most recent version of the NCAR Community Climate Model, CCM2. In addition to in-depth information about running the CCM2 model code, the User's Guide gives a detailed description of the code organization and data structures so that CCM2 can be modified by users as mandated by their particular ...
Bath, Linda, Rosinski, James, Olson, Jerry   +2 more
openaire   +1 more source

Comparative energetics analysis of CCM2 with different horizontal resolutions

Climate Dynamics, 1997
Comprehensive global energetics analysis is carried out for the NCAR CCM2 with different horizontal resolutions of R15, T42, T63, and T106 to assess the effect of various model truncations on the global energetics characteristics in climate models. Both the energy levels and energy transformations are examined over the zonal wave number domain during a
A. Hasegawa, H. L. Tanaka, H. Hirakuchi, S. Taguchi   +3 more
openaire   +1 more source

Description of the NCAR Community Climate Model (CCM2)

1993
This report presents the details of the governing equations, physical parameterizations, and numerical algorithms defining the version of the NCAR Community Climate Model designated CCM2 that represents a wholly new state-of-the-art atmospheric general circulation model, both functionally and in terms of its implementation and represents a major break ...
Hack, James, Boville, Byron, Briegleb, Bruce, Kiehl, Jeffrey, Williamson, David   +4 more
openaire   +1 more source

CCM2 Datasets and Circulation Statistics

1993
This technical report documents the data findings from simulations and condensations which includes actual simulations, climatological monthly averaged sea surface temperature; 10 and 20 year simulation cases; simulation with BATS and other resolutions.
openaire   +1 more source

Diurnal Heating and Cloudiness in the NCAR Community Climate Model (CCM2)

Journal of Climate, 1994
In this paper, the authors assess the suitability of the heating fileds in the latest version of the National Center for Atmospheric Research (NCAR) Community Climate Model (CCM2) for modeling the thermal forcing of atmospheric tides. Accordingly, diurnal variations of the surface pressure, outgoing longwave radiation (OLR), cloudiness, and ...
Ruth S. Lieberman, Conway B. Leovy, Byron A. Boville, Bruce P. Briegleb   +3 more
openaire   +1 more source

Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations

Mammalian Genome, 2006
Cerebral cavernous malformations are vascular defects of the central nervous system consisting of clusters of dilated vessels that are subject to frequent hemorrhaging. The genes mutated in three forms of autosomal dominant cerebral cavernous malformations have been cloned, but it remains unclear which cell type is ultimately responsible for the lesion.
Nicholas W, Plummer, Teresa L, Squire, Sudha, Srinivasan, Elizabeth, Huang, Jon S, Zawistowski, Hiroaki, Matsunami, Laura P, Hale, Douglas A, Marchuk   +7 more
openaire   +2 more sources