Results 11 to 20 of about 7,007 (197)
CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae. [PDF]
PLoS ONE, 2011 In gram-positive bacteria, the transcriptional regulator CcpA is at the core of catabolite control mechanisms. In the human pathogen Streptococcus pneumoniae, links between CcpA and virulence have been established, but its role as a master regulator in ...
Sandra M Carvalho +3 more
doaj +8 more sources
Effect of a glucose impulse on the CcpA regulon in
BMC Microbiology, 2009 Background The catabolite control protein A (CcpA) is a member of the LacI/GalR family of transcriptional regulators controlling carbon-metabolism pathways in low-GC Gram-positive bacteria.
Engelmann Susanne +7 more
doaj +7 more sources
Staphylococcus aureus CcpA Affects Biofilm Formation [PDF]
Infection and Immunity, 2008 ABSTRACT Biofilm formation in Staphylococcus aureus under in vitro growth conditions is generally promoted by high concentrations of sugar and/or salts. The addition of glucose to routinely used complex growth media triggered biofilm formation in S. aureus strain SA113. Deletion of
Seidl, K +5 more
openaire +6 more sources
CcpA Is Important for Growth and Virulence of Enterococcus faecium [PDF]
Infection and Immunity, 2014 ABSTRACT The collagen adhesin Acm was the first virulence determinant reported to be important for the pathogenesis of Enterococcus faecium in a rat infective endocarditis model. We had previously reported that there was a slight growth delay associated with acm allelic replacement (
Somarajan, Sudha R +4 more
core +4 more sources
The Global Regulator CcpA of Listeria monocytogenes Confers Sensitivity to Antimicrobial Fatty Acids [PDF]
Frontiers in Microbiology, 2022 Free fatty acids (FFAs) are known to exhibit antimicrobial and anti-virulent properties against bacterial pathogens. Specific FFAs, such as lauric acid (LA; C12:0), exert both effects against the foodborne pathogen Listeria monocytogenes: at low levels ...
Rikke S. S. Thomasen +10 more
doaj +2 more sources
PLoS ONE, 2018 The success of Staphylococcus aureus as a pathogen is due in part to its ability to adapt to changing environmental conditions using signal transduction pathways, such as metabolite- responsive regulators and two-component systems. S.
Joseph M Reed +8 more
doaj +2 more sources
Assessment of CcpA-mediated catabolite control of gene expression in
BMC Microbiology, 2008 Background The catabolite control protein CcpA is a transcriptional regulator conserved in many Gram-positives, controlling the efficiency of glucose metabolism.
Buist Girbe +4 more
doaj +5 more sources
CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis [PDF]
Microbiology, 2011 Staphylococcus epidermidis is an opportunistic bacterium whose infections often involve the formation of a biofilm on implanted biomaterials. In S. epidermidis, the exopolysaccharide facilitating bacterial adherence in a biofilm is polysaccharide intercellular adhesin (PIA), whose synthesis requires the enzymes encoded within the ...
Sadykov MR +11 more
openaire +4 more sources
CcpA‐mediated repression of Clostridium difficile toxin gene expression
Molecular Microbiology, 2010 SummaryThe presence of glucose or other rapidly metabolizable carbon sources in the bacterial growth medium strongly represses Clostridium difficile toxin synthesis independently of strain origin. In Gram‐positive bacteria, carbon catabolite repression (CCR) is generally regarded as a regulatory mechanism that responds to carbohydrate availability.
Antunes, Ana +2 more
openaire +4 more sources
BMC Genomics, 2012 Background Clostridium acetobutylicum has been used to produce butanol in industry. Catabolite control protein A (CcpA), known to mediate carbon catabolite repression (CCR) in low GC gram-positive bacteria, has been identified and characterized in C ...
Ren Cong +6 more
doaj +2 more sources