Results 201 to 210 of about 71,715 (302)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Engineered CCR2 Cell Membrane-Wrapped Cepharanthine Liposomes for Potential Targeted Attenuation of Acute Lung Injury. [PDF]

Cells
Qing Y, Zhao W, Xue L, Luo Y, Gao Y, Sun X, Li F, Dai L, Mo J, Xu G, Bi Z, Yang S, Hee WT, Li J, Leng L.   +14 more
europepmc   +1 more source

Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β [PDF]

, 2018
et al,, Gelman, Andrew E, Hsiao, Hsi-Min, Kreisel, Daniel, Lavine, Kory J, Li, Wenjun, Liu, Yongjian, Luehmann, Hannah P, Puri, Varun, Ruiz-Perez, Daniel, Scozzi, Davide, Spahn, Jessica H, Takahashi, Tsuyoshi, Tanaka, Satona, Turam, Cem   +14 more
core   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis. [PDF]

Front Immunol
Zhao G, Guo C, Li X, Tan L, Chen X, Tian F, Zhang L, Wang X, Cui J.   +8 more
europepmc   +1 more source

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan, Jiayu Zhang, Xinyi Ye, Huihong Wang, Hang Li, Weirong Li, Huifei Wu, Wei Zhao   +7 more
wiley   +1 more source

Mass Cytometry Workflow to Achieve High‐Dimensional Immunophenotyping in Resource‐Limited or Decentralized Environments

Current Protocols, Volume 6, Issue 3, March 2026.
Abstract Globally, regional and remote communities are burdened by both an increased prevalence and worse prognosis of many infectious and chronic diseases. However, largely owing to logistical challenges, these communities are under‐represented in clinical trials and research studies.
Natalie Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas de St Groth, Helen McGuire   +13 more
wiley   +1 more source

Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation. [PDF]

Nat Commun
Vasamsetti SB, Sadaf S, Uddin MA, Shen J, Johny E, Mondal A, Florentin J, Lei L, Mannan A, Rao KS, Sembrat J, Rojas M, Sipula I, Kastroll J, Jurczak MJ, Shiva S, O'Doherty RM, Yechoor V, Dutta P.   +18 more
europepmc   +1 more source

Single‐Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Mice with natural microbiota show expected ageing spleen trends: naïve T cell loss with effector‐memory expansion, mature B cell shifts, Gzmk+ CD8+ T cell heterogeneity, diminished NK cytotoxicity and pro‐inflammatory macrophages. Chronic stress modestly counteracted these age‐related changes.
Chinna Susan Philip, Igor Filippov, Uku Haljasorg, Pärt Peterson   +3 more
wiley   +1 more source

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells

MedComm, Volume 7, Issue 3, March 2026.
HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosterone levels by desensitization of GnRHR, the downregulation of hTERT expression and telomerase activity, and the enhancement of Anticancer immunity.
Jae Hyeon Park, Joo Chan Lee, Swati Sharma, Chunxue Jiang, Haeun Lee, Hyun‐Ju Park, Hyung Sik Kim   +6 more
wiley   +1 more source