Results 201 to 210 of about 65,957 (231)

Identification of immune cells in benign and malignant thymus tumors: a Mendelian randomization study. [PDF]

Ann Med Surg (Lond)
Yan N, Wang S, Ruan L, Zhang Y, Zhang D, Hu S, Xiong W, Zhang W, Yao C, Wei Y.   +9 more
europepmc   +1 more source

Supplementary Figure 6 from Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody–Drug Conjugate TAK-500

Vicky A. Appleman, Atsushi Matsuda, Michelle L. Ganno, Dong Mei Zhang, Emily Rosentrater, Angel E. Maldonado Lopez, Angelo Porciuncula, Tiquella Hatten, Camilla L. Christensen, Samantha A. Merrigan, Hong Myung Lee, Min Young Lee, Charlotte I. Wang, Linlin Dong, Jian Huang, Natasha Iartchouk, Jianing Wang, He Xu, Tomoki Yoneyama, Konstantin I. Piatkov, Satyajeet Haridas, Carole E. Harbison, Richard C. Gregory, Alexander Parent, Neil Lineberry, Chris Arendt, Kurt A. Schalper, Adnan O. Abu‐Yousif   +27 more
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Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation

Bartolini R, Sharma D, Wilson GJ, Dunphy G, Cavanagh J, Halawa HA, Cole J, Weidt S, Gardner-Stephen K, Graham GJ.   +9 more
europepmc   +1 more source

Targeting monocyte heterogeneity in aortic aneurysms: immunomodulatory strategies and therapeutic opportunities. [PDF]

Front Cardiovasc Med
Dinc R, Ardic N.
europepmc   +1 more source

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Myeloid CCR2 Promotes Atherosclerosis after AKI

Journal of the American Society of Nephrology, 2022
Background The risk of cardiovascular events rises after AKI. Leukocytes promote atherosclerotic plaque growth and instability. We established a model of enhanced remote atherosclerosis after renal ischemia-reperfusion (IR) injury and investigated the underlying inflammatory mechanisms. Methods
Anne M. Hüsing, Vera C. Wulfmeyer, Svenja Gaedcke, Susanne V. Fleig, Song Rong, David DeLuca, Hermann Haller, Roland Schmitt, Sibylle von Vietinghoff   +8 more
openaire   +2 more sources

CCR2 Antagonists

Current Topics in Medicinal Chemistry, 2010
Inhibition of CCR2 has been considered as a target for multiple therapeutic diseases including autoimmune disease, atherosclerosis, pain, and metabolic disease, based in part on the critical role this receptor plays on monocyte migration. Numerous companies have reported programs to identify CCR2 antagonists.
Mary, Struthers, Alexander, Pasternak
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CCR1 and CCR2 Antagonists

Current Topics in Medicinal Chemistry, 2014
Chemokines constitute a family of small heparin-binding proteins which orchestrate the infiltration of leukocytes during inflammation, but also directly influence other physiological and pathophysiological processes. In humans, more than 40 chemokines are known binding to around 18 G-protein-coupled receptors. A non-redundant role of certain chemokines
Henning W, Zimmermann, Viktor, Sterzer, Hacer, Sahin   +2 more
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Recent developments in CCR2 antagonists

Expert Opinion on Therapeutic Patents, 2009
Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and memory T cells by means of their binding to its specific cell-surface receptor, CC-chemokine receptor-2 (CCR2). CCR2 belongs to the G-protein-coupled seven-transmembrane receptor superfamily.
Mingde, Xia, Zhihua, Sui
openaire   +2 more sources

Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells.

The Journal of Immunology, 1997
Abstract We have derived anti-human CCR2-specific mAbs by immunization with synthetic peptides corresponding to CCR2 sequences presumably involved in the interaction with its ligand(s). The characterization of these mAbs includes the ability to recognize the CCR2 receptor specifically, as well as the function based on their ability to ...
J M, Frade, M, Mellado, G, del Real, J C, Gutierrez-Ramos, P, Lind, C, Martinez-A   +5 more
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Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

Atherosclerosis, 2010
CCR2, the receptor for monocyte chemoattractant protein 1 (MCP1), is involved in atherosclerosis and abdominal aortic aneurysms (AAAs). Here, we explored the potential beneficial blockade of the MCP1/CCR2 pathway.We applied an AAA model in aging apolipoprotein E deficient mice with pre-existing atherosclerotic lesions.
Waard, V. de, Bot, I., Jager, S.C.A. de, Talib, S., Egashira, K., Vries, M.R. de, Quax, P.H.A., Biessen, E.A.L., Berkel, T.J.C. van   +8 more
openaire   +3 more sources