Results 221 to 230 of about 71,715 (302)

Mesenchymal stem cell-derived apoptotic extracellular vesicles loaded with Prussian blue nanoparticles attenuate severe acute pancreatitis via neutrophil extracellular traps resolution and acinar-ductal metaplasia promotion. [PDF]

J Nanobiotechnology
Xu W, Cai W, Wu J, Hou X, Qi X, Wei Z, Cheng Y, Zheng Y, Cui B, He J.   +9 more
europepmc   +1 more source

CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

Journal of Clinical Investigation, 2006
S. Weisberg, Deborah Hunter, R. Huber, Jacob Lemieux, S. Slaymaker, K. Vaddi, I. Charo, R. Leibel, A. Ferrante   +8 more
semanticscholar   +1 more source

Methylmalonic Acid, an Aging‐Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2‐STAT3/VEGF Signaling Axis

Aging Cell, Volume 25, Issue 3, March 2026.
Our study reveals that elevated MMA in aged intervertebral discs promotes degeneration by activating the CCL7/JAK2‐STAT3/VEGF signaling axis, which drives pathological vascularization. Therapeutically, the VEGFR inhibitor lenvatinib attenuated this process, identifying disc vascularization as a promising therapeutic target for IVDD.
Yuanzhang Jin, Runtian Zhou, Xiaonan Wang, Haifeng Liu, Xiaofeng Zhao, Doudou Jing, Bin Zhao   +6 more
wiley   +1 more source

CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis. [PDF]

MedComm (2020)
Chen J, Guan X, Wu W, Wu L, Liu Y, Zeng D, Dang J, Zhao J, Wang J, Yuan J, Fan X, Pan Y, Olsen N, Zheng SG.   +13 more
europepmc   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

The pro-fibrogenic role of SPP1⁺ macrophages in medical implant fibrosis: mechanisms and therapeutic opportunities. [PDF]

Front Immunol
Yu M, Fu J.
europepmc   +1 more source

Sex Differences in Lung Immunity

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Biological sex has a significant impact on how the immune system develops and responds to foreign and self‐antigens. Sex differences exist in innate and adaptive immune cells, both at homeostasis and in the context of infection and inflammatory diseases such as asthma, cancer, and autoimmune disorders.
Franz Puttur, Clare M. Lloyd
wiley   +1 more source

The STAT3-ZEB1 axis contributes to CCL2-mediated resistance to osimertinib in lung cancer. [PDF]

Front Oncol
Chang TH, Tsai MF, Wu SG, Liu YN, Wu HD, Tsai TH, Jheng HN, Hsu CL, Yeh PS, Shih JY.   +9 more
europepmc   +1 more source

Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders. [PDF]

J Med Chem
Essa K, Ortiz Zacarías NV, Roth S, Xin BT, de Winter S, van der Horst C, Bleijs B, de Heiden RA, Voulgaraki R, Neubert E, Ovaa H, Danen EHJ, Mulder MPC, Moreau K, van der Es D, Heitman LH.   +15 more
europepmc   +1 more source

Activation of β2-Adrenergic Receptor Alleviates Viral Myocarditis by Regulating Energy Metabolism in Monocyte-derived Macrophages via the AMPK Pathway. [PDF]

Inflammation
Li QL, Guo YX, Li JF, Xie HB, Qian J, Wu WF.   +5 more
europepmc   +1 more source