Results 271 to 280 of about 71,715 (302)
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Current Topics in Medicinal Chemistry, 2014
Chemokines constitute a family of small heparin-binding proteins which orchestrate the infiltration of leukocytes during inflammation, but also directly influence other physiological and pathophysiological processes. In humans, more than 40 chemokines are known binding to around 18 G-protein-coupled receptors. A non-redundant role of certain chemokines
Henning W, Zimmermann +2 more
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Chemokines constitute a family of small heparin-binding proteins which orchestrate the infiltration of leukocytes during inflammation, but also directly influence other physiological and pathophysiological processes. In humans, more than 40 chemokines are known binding to around 18 G-protein-coupled receptors. A non-redundant role of certain chemokines
Henning W, Zimmermann +2 more
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Life Science, 2021
Evidence suggests that uncontrolled immune system responses and their components play a significant role in developing rheumatoid arthritis (RA), which is considered an autoimmune disease (AD).
Fatemeh Moadab +2 more
semanticscholar +1 more source
Evidence suggests that uncontrolled immune system responses and their components play a significant role in developing rheumatoid arthritis (RA), which is considered an autoimmune disease (AD).
Fatemeh Moadab +2 more
semanticscholar +1 more source
Recent developments in CCR2 antagonists
Expert Opinion on Therapeutic Patents, 2009Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and memory T cells by means of their binding to its specific cell-surface receptor, CC-chemokine receptor-2 (CCR2). CCR2 belongs to the G-protein-coupled seven-transmembrane receptor superfamily.
Mingde, Xia, Zhihua, Sui
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Frontiers in Immunology
CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple organ systems by modulating the recruitment and ...
Shan Guo +7 more
semanticscholar +1 more source
CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple organ systems by modulating the recruitment and ...
Shan Guo +7 more
semanticscholar +1 more source
The role of CCL2/CCR2 axis in cancer and inflammation: The next frontier in nanomedicine.
Advanced Drug Delivery ReviewsThe communication between cells and their microenvironment represents an intrinsic and essential attribute that takes place in several biological processes, including tissue homeostasis and tissue repair.
Sabina Pozzi, Ronit Satchi Fainaro
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Biomaterials, 2021
Impaired wound healing presents great health risks to patients. While encouraging, the current clinical successes of mesenchymal stromal cell (MSC)-based therapies for tissue repair have been limited. Genetic engineering could endow MSCs with more robust
Shuhong Kuang +12 more
semanticscholar +1 more source
Impaired wound healing presents great health risks to patients. While encouraging, the current clinical successes of mesenchymal stromal cell (MSC)-based therapies for tissue repair have been limited. Genetic engineering could endow MSCs with more robust
Shuhong Kuang +12 more
semanticscholar +1 more source
Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells.
The Journal of Immunology, 1997Abstract We have derived anti-human CCR2-specific mAbs by immunization with synthetic peptides corresponding to CCR2 sequences presumably involved in the interaction with its ligand(s). The characterization of these mAbs includes the ability to recognize the CCR2 receptor specifically, as well as the function based on their ability to ...
J M, Frade +5 more
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Atherosclerosis, 2010
CCR2, the receptor for monocyte chemoattractant protein 1 (MCP1), is involved in atherosclerosis and abdominal aortic aneurysms (AAAs). Here, we explored the potential beneficial blockade of the MCP1/CCR2 pathway.We applied an AAA model in aging apolipoprotein E deficient mice with pre-existing atherosclerotic lesions.
Waard, V. de +8 more
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CCR2, the receptor for monocyte chemoattractant protein 1 (MCP1), is involved in atherosclerosis and abdominal aortic aneurysms (AAAs). Here, we explored the potential beneficial blockade of the MCP1/CCR2 pathway.We applied an AAA model in aging apolipoprotein E deficient mice with pre-existing atherosclerotic lesions.
Waard, V. de +8 more
openaire +3 more sources
2021
Aims. The rate of progression of HIV-1 disease exhibits a remarkable variation among different individuals. Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. associated with a delayed progression to disease.
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Aims. The rate of progression of HIV-1 disease exhibits a remarkable variation among different individuals. Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. associated with a delayed progression to disease.
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Small molecule CCR2 antagonists
2007Monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. During inflammatory conditions, the production of MCP-1 is upregulated in both immune and non-immune cell types including macrophages, mast cells, fibroblasts, endothelial and epithelial cells, smooth muscle cells, and astrocytes.
Paul J. Higgins +2 more
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