Results 211 to 220 of about 54,562 (253)

CCR5 and inflammatory storm

Ageing Research Reviews
Chemokines and their corresponding receptors play crucial roles in orchestrating inflammatory and immune responses, particularly in the context of pathological conditions disrupting the internal environment. Among these receptors, CCR5 has garnered considerable attention due to its significant involvement in the inflammatory cascade, serving as a ...
Yuting Lin, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Gang Pei, Meiyu Lin, Jingbo Yu, Xuan Liu, Huiqin Wang, Junpeng Long, Qian Yan, Jinping Liang, Jiao Yao, Fan Yi, Lei Meng, Yong Tan, Naihong Chen, Yantao Yang, Qidi Ai   +19 more
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Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery

Journal of the Neurological Sciences, 2011
Immune-mediated damage to the central nervous system (CNS) is an important contributor to many CNS diseases, including epilepsy. Chemokines play a role in leukocyte recruitment to, and migration across, the blood-brain barrier (BBB) during many such processes. We previously investigated the role of the chemokine receptor CCR5 in a rat model of epilepsy
Elena, Marusich, Jean-Pierre, Louboutin, Alena A, Chekmasova, David S, Strayer   +3 more
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Resistance to CCR5 antagonists

Current Opinion in HIV and AIDS, 2007
CCR5 antagonists disrupt crucial interactions between HIV envelope glycoprotein gp120 and CCR5, preventing virus binding and entry. Current antiretroviral agents target viral proteins, whereas CCR5 antagonists bind to the host cell. This novel mechanism of action is posing new challenges to our understanding of drug resistance.Possible mechanisms of ...
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Maraviroc: a new CCR5 antagonist

Expert Review of Anti-infective Therapy, 2009
Maraviroc is a small molecule and a member of a new class of antiretroviral compounds known as CCR5 antagonists, which block R5-tropic HIV entry into CD4 cells. HIV entry into the cell requires binding to a CD4 molecule and, in the majority of cases, to a coreceptor, either chemokine coreceptor 4 (CXCR4) or 5 (CCR5). In August 2007, the US FDA approved
Shilpa, Sayana, Homayoon, Khanlou
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Middle management of CCR5

Nature Reviews Immunology, 2019
Levels of CCR5 expression by CD4+ T cells, which influence the outcome of HIV-1 infection, are modulated by polymorphism of a non-coding RNA that affects mRNA stability.
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Combinatorial synthesis of CCR5 antagonists

Bioorganic & Medicinal Chemistry Letters, 2001
Herein we report the preparation of a combinatorial library of compounds with potent CCR5 binding affinity. The library design was aided by SAR generated in a traditional medicinal chemistry effort. Compounds with novel combinations of subunits were discovered that have high binding affinity for the CCR5 receptor.
C A, Willoughby, S C, Berk, K G, Rosauer, S, Degrado, K T, Chapman, S L, Gould, M S, Springer, L, Malkowitz, W A, Schleif, D, Hazuda, M, Miller, J, Kessler, R, Danzeisen, K, Holmes, J, Lineberger, A, Carella, G, Carver, E A, Emini   +17 more
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CCR5 is characteristic of Th1 lymphocytes

Nature, 1998
CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites.
P, Loetscher, M, Uguccioni, L, Bordoli, M, Baggiolini, B, Moser, C, Chizzolini, J M, Dayer   +6 more
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Recent advances of CCR5 antagonists

Current Opinion in HIV and AIDS, 2006
The interaction of the beta-chemokine receptor CCR5 with the HIV-1 envelope glycoprotein gp120 is critical for viral entry. Therefore, CCR5 seems to be a promising target for inhibition of HIV-1 replication. A number of attempts have been made to identify small-molecule CCR5 antagonists as novel antiretroviral agents.
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???????????????? ???????????????????? ?? ???????????? ???????????????????????????? ?????????????????? ???? ???????????????? ????????-?????????????????????????? ???????? CCR5 del32

2021
Five Ukrainian populations have been genotyped for a deletion polymorphism del32 in CCR5 gene. It has been shown that frequency of this allele in Ukrainians is similar to that of the other Slavic populations.
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Structure prediction of the protein ccr5 delta 32 and structure comparison with ccr5

International Journal of Pharma and Bio Sciences, 2016
Human immunodeficiency virus (HIV) is an obligate intracellular parasite of the CD4 + T-cells. This virus targets and kills helper T cells that play a vital role in immune response. Studies have shown that the interaction between the viral glycoprotein and host proteins like CD4 and Chemokine receptor type 5 (CCR5) enable the virus to get into the ...
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