Results 111 to 120 of about 824,117 (206)

Profile of maraviroc: a CCR5 antagonist in the management of treatment-experienced HIV patients

, 2010
Thore LorenzenIFI Institute for Interdisciplinary Medicine, Hamburg, GermanyAbstract: Maraviroc is the first and, so far, the only licensed representative of the class of chemokine receptor type 5 (CCR5) inhibitors used for the treatment of human ...
Thore Lorenzen
core  

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

, 2016
To identify a CCR5 antagonist as an HIV-1 entry inhibitor, we designed a novel series of indane derivatives based on conformational considerations.
Nancy Contel (2139562), Taisheng Huang (2139598), Hao Feng (54208), Chu-Biao Xue (2139553), Laurine Galya (2245537), Robert Newton (104105), Michael Xia (2139535), Joseph Glenn (2139586), David Meloni (2139601), Douglas Keller (2245546), Jiacheng Zhou (2245543), Kim Solomon (2245549), Tom Emm (2139550), Gregory Hollis (2245555), Ganfeng Cao (2139559), Peggy Scherle (2139556), Lihua Chen (141443), Swamy Yeleswaram (2139574), Anlai Wang (2139595), Sharon Diamond (2139568), Kris Vaddi (2139544), Brian Metcalf (2139589), Niu Shin (2245552), Fredric Baribaud (2245558), Steven Friedman (2193682), Changsheng Zheng (2139583), Mei Li (217363), Ling Kong (419944), Rajan Anand (1445953), Ke Zhang (115386), Bitao Zhao (2245540)   +30 more
core   +1 more source

Computational modeling of human coreceptor CCR5 antagonist as a HIV-1 entry inhibitor: using an integrated homology modeling, docking, and membrane molecular dynamics simulation analysis approach

Journal of Biomolecular Structure and Dynamics, 2013
Chemokine receptor 5 (CCR5) is an integral membrane protein that is utilized during human immunodeficiency virus type-1 entry into host cells. CCR5 is a G-protein coupled receptor that contains seven transmembrane (TM) helices.
C. Gadhe, G. Kothandan, S. Cho
semanticscholar   +1 more source

The importance of co-receptors in antiretroviral therapy and novel studies on non-peptide, small molecule chemokine receptor type 5 (CCR5) antagonists

İstanbul Journal of Pharmacy
Human immunodeficiency virus (HIV) infection is a major health problem worldwide. Antiretroviral Therapy (ART) involves a combination of HIV drugs (called HIV treatment regimen). However, ART resis5 tance, which emerged because of evolutionary processes,
Dilek Aksoy, Füsun Göktaş Ur
doaj   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Blockade of CCR5+ T Cell Accumulation in the Tumor Microenvironment Optimizes Anti‐TGF‐β/PD‐L1 Bispecific Antibody

Advanced Science
In the previous studies, anti‐TGF‐β/PD‐L1 bispecific antibody YM101 is demonstrated, with superior efficacy to anti‐PD‐L1 monotherapy in multiple tumor models.
Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Bin Zhao, Zhuoyang Shen, Shengtao Hu, Chaomei Zhang, Xiaojun Zhang, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu, Zhijun Dai, Kongming Wu   +14 more
doaj   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Periodontal Salutogenesis: Why Are Some People Resistant to Oral Microbial Dysbiosis and Destructive Inflammation?

Journal of Periodontal Research, EarlyView.
Emerging evidence suggests that periodontal health is not simply the absence of disease, but the result of a dynamic interaction between biological resilience, healthy lifestyles, adaptive coping mechanisms, and supportive environments. This results in a strong sense of coherence, which is not only a psychological state but also a biological state ...
Bruno G. Loos, Magda Feres, William V. Giannobile, Hatice Hasturk, Egija Zaura   +4 more
wiley   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor

Antioxidants
Sarcopenia corresponds to a decrease in muscle mass and strength. CCL5 is a new myokine whose expression, along with the CCR5 receptor, is increased in sarcopenic muscle.
Francisco Aguirre, Franco Tacchi, Mayalen Valero-Breton, Josué Orozco-Aguilar, Sabrina Conejeros-Lillo, Josefa Bonicioli, Renata Iturriaga-Jofré, Daniel Cabrera, Jorge A. Soto, Mauricio Castro-Sepúlveda, Marianny Portal-Rodríguez, Álvaro A. Elorza, Andrea Matamoros, Felipe Simon, Claudio Cabello-Verrugio   +14 more
doaj   +1 more source