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SCGN and STAT3 Expressions Are Associated With the Prognosis of ccRCC
Pathology Research and Practice, 2023Clear cell renal cell carcinoma (ccRCC) is highly heterogeneous and accounts for about 70% of RCC. Its prognosis is worse than that of most histological types of RCC. In order to find potential biomarkers that may influence the prognosis and survival in ccRCC patients, we explored the expressions of STAT3, PDL1 and SCGN (secretagogin) in ccRCC based on
Dandan Zhang, Chong Lai, Tang Jinlong
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Chemerin Tips the Scales in ccRCC to Evade Ferroptosis
Cancer Discovery, 2021Abstract Summary: Obesity is both a risk factor for the development of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), and a prognostically protective factor for clinical outcomes.
Ed Reznik, Hui Jiang, A. Ari Hakimi
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Urologic Oncology: Seminars and Original Investigations, 2016
Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer after prostate and bladder cancer but has the highest rate of mortality affecting over 40% of patients. microRNAs (miRNAs) are small noncoding RNAs that have become potential biomarkers and molecular targets for cancer treatment. Molecular markers such as miRNAs may have
Kristof Harda +2 more
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Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer after prostate and bladder cancer but has the highest rate of mortality affecting over 40% of patients. microRNAs (miRNAs) are small noncoding RNAs that have become potential biomarkers and molecular targets for cancer treatment. Molecular markers such as miRNAs may have
Kristof Harda +2 more
exaly +3 more sources
Science Signaling
Targeting a driver of TBK1 kinase activity may slow the growth of kidney tumors.
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Targeting a driver of TBK1 kinase activity may slow the growth of kidney tumors.
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The Warburg effect in hominis: isotope-resolved metabolism in ccRCC
Nature Reviews Urology, 2018A recently published study has evaluated metabolism in human clear cell renal carcinomas (ccRCCs) using intraoperative [13C]glucose infusion during surgical procedures. The findings demonstrate aerobic glycolysis and repression of the Krebs cycle, confirming the existence of the Warburg effect in ccRCC tumours in vivo.
Daniel R, Crooks, W Marston, Linehan
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Abstract IA025: Nuclear speckles in ccRCC
Cancer ResearchAbstract Inside the cell nucleus, nuclear speckles are a predominant type of nuclear body present in the cells throughout our bodies. While first observed by Ramon y Cajal over 100 years ago, speckles have only recently been recognized as a major layer of gene regulation that boosts gene expression by assisting multiple steps of RNA ...
Sana Mir +3 more
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TAOK3 promotes ccRCC progression by phosphorylating ASAP2
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseClear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is characterized by high metastatic propensity and poor clinical outcomes. Elucidating the molecular mechanisms underlying ccRCC progression is therefore essential for the development of more effective therapeutic strategies..
Xiaoli, Zheng +8 more
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New insights into the ccRCC microenvironment
Nature Reviews Nephrology, 2021openaire +2 more sources