Results 121 to 130 of about 23,244 (239)
HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators [PDF]
, 2019 Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases.
core +2 more sources
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Cancer Biology & TherapyUbiquitin-specific protease 7 (USP7) involves in various human cancers due to its capacity for binding and stabilizing specific target proteins through deubiquitylation, but its roles in clear cell renal cell carcinoma (ccRCC) development remains unknown.
Hongsheng Li +5 more
doaj +1 more source
Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting
MedComm, Volume 7, Issue 9, September 2026.This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma +5 more
wiley +1 more source
SAM of ccRCC tumors against the rest of them.
, 2020 ccRCC = Clear cell renal carcinoma.
Guillermo de Velasco (3457934) +13 more
core +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, Volume 59, Issue 9, September 2026.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
, 2014 Mean levels of differentially expressed proteins among ccRCC patients (n = 58), healthy controls (n = 64), pre- and post-operatives ccRCC samples (n = 20).
Yan Gao (93649) +8 more
core +1 more source
Immunohistochemical staining for KCa3.1 in ccRCC and oncocytoma.
, 2015 Immunohistochemical staining for KCa3.1 in ccRCC (A) and oncocytoma (B) shows strong staining of tumor vessels (long arrows) in both tumor subtypes.
Ralf Köhler (34264) +8 more
core +1 more source
BMC UrologyBackground Currently, no useful serum markers exist for clear cell renal cell carcinoma (ccRCC), making early detection challenging as diagnosis relies solely on imaging tests. Radiation exposure is also a concern due to multiple required CT examinations
Shotaro Nakanishi +5 more
doaj +1 more source
Immunofluorescent staining for CD8 and KCa3.1 in ccRCC and oncocytoma.
, 2015 Immunofluorescence of CD8 (red) and KCa3.1 (green) in ccRCC (A) and oncocytoma (B). Large arrows indicate T cells positive for CD8 and KCa3.1. Small arrows indicate T cells positive for CD8 but KCa3.1-negative.
Ralf Köhler (34264) +8 more
core +1 more source