Results 111 to 120 of about 23,244 (239)

Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinomaResearch in context

EBioMedicine, 2019
Background: The molecular mechanism underlying clear cell renal cell carcinoma (ccRCC) metastasis remains unclear. We therefore aimed to elucidate the role of IMPA2 in ccRCC metastatic progression.
Yuh-Feng Lin, Jian-Liang Chou, Jeng-Shou Chang, I-Jen Chiu, Hui-Wen Chiu, Yuan-Feng Lin   +5 more
doaj   +1 more source

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Comparative profiling of serum peptides from preoperative ccRCC patients (red), healthy controls (green), and postoperative ccRCC patients (blue).

, 2014
A. Bivariate plot of preoperative ccRCC patients (red), healthy controls (green), and postoperative ccRCC patients (blue) in the component analysis. B.
Yan Gao (93649), Jin Yang (86490), Liying Liu (132271), Xiaofei Wang (135107), Yannan Qin (125322), Juan Yang (384075), Chen Huang (202847), Tusheng Song (654368), Lingyu Zhao (654367)   +8 more
core   +1 more source

Univariate analysis of overall survival in 526 ccRCC patients.

, 2022
Univariate analysis of overall survival in 526 ccRCC patients.
Tie Chong (655561), Haibin Zhou (573069), Mei Gao (503320), Mingrui Li (2567635), Yibing Guan (9417680), Juanhua Tian (9417686), Fangshi Xu (9417683), Ziyan Wan (9417689), Minxin He (12085178)   +8 more
core   +1 more source

A Case of Cytokine Release Syndrome (CRS) Related to Treatment With Lenvatinib Plus Pembrolizumab for Metastatic Clear Cell Renal Cell Carcinoma

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infection and immunotherapy. Due to its nonspecific presentation, distinguishing CRS from other life‐threatening conditions remains challenging.
Kei Nagase, Hiroaki Kakinoki, Kazuki Nakamura, Yukako Yamaguchi, Shuhei Kusano, Yuka Kakinoki, Maki Kawasaki, Kazuma Udo, Shohei Tobu, Mitsuru Noguchi   +9 more
wiley   +1 more source

SLC3A1 Mitigates Ferroptosis and Promotes Enzalutamide Resistance in Prostate Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
SLC3A1 is a promising therapeutic target for advanced prostate cancer. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related mortality in aging male, with resistance to enzalutamide (Enza) representing a major therapeutic challenge. This study identifies SLC3A1 as a key driver of Enza resistance.
Peng Liu, Haocheng Zhang, Yuhang Qian, Jiong Zhang, Xiaojun Deng, Bin Sun   +5 more
wiley   +1 more source

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source

Expression of miR-141-3p and miR-145-5p in ccRCC tissue.

, 2016
Expression of miR-141-3p and miR-145-5p in malignant (ccRCC) and non-malignant (N) renal tissue of 27 ccRCC patients was measured by RT-qPCR. A) and B) show expression differences between paired normal and ccRCC samples. In C) ccRCC tumors are split into
Ergin Kilic (157051), Jonas Busch (2571199), Klaus Jung (65489), Julia Liep (849025), Hellmuth A. Meyer (303526), Anja Rabien (2565049)   +5 more
core   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source