Results 91 to 100 of about 23,244 (239)

Chaetocin Induces Ferroptosis in Cisplatin‐Resistant Ovarian Cancer Cells Through Neddylation‐Mediated TFRC Upregulation

Phytotherapy Research, EarlyView.
Chaetocin induces ferroptosis in cisplatin‐resistant ovarian cancer cells through neddylation‐mediated TFRC upregulation. ABSTRACT Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure.
Hanfei Xie, Wumin Dai, Lu Sun, Wangang Gong, Tao Zhu, Yingli Zhang   +5 more
wiley   +1 more source

Positive KCa3.1 currents detected in ccRCC by patchclamping.

, 2015
(A) Electrophysiological characterization of KCa3.1 channels in ccRCC. In primary ccRCC, KCa3.1 whole-cell currents exhibited typical KCa3.1 features such as inward rectification at positive voltage and complete inhibition by the selective KCa3.1 blocker,
Ralf Köhler (34264), Maj Rabjerg (127189), Niels Marcussen (497185), Linda Sevelsted-Møller (718407), Boye L. Jensen (718409), Lars Koch Hansen (718406), Steen Walter (718408), Aida Oliván-Viguera (127186), Line Jensen (109124)   +8 more
core   +1 more source

BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells

Open Life Sciences
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. A few genes, such as BAP1, are associated with the tumorigenesis of ccRCC. Mutations in BAP1 are related to a proportion of ccRCCs. In this study, to explore the functional
Wu Ying, Li Xue-Ying, Chen Jin-Dong, Pan You-Fu   +3 more
doaj   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Long Non-Coding RNA LUCAT1 Promotes Proliferation and Invasion in Clear Cell Renal Cell Carcinoma Through AKT/GSK-3β Signaling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Long non-coding RNAs (lncRNAs) have emerged as new regulators and biomarkers in several cancers. However, few lncRNAs have been well characterized in clear cell renal cell carcinoma (ccRCC). Methods: We investigated the lncRNA expression
Zaosong Zheng, Fengjin Zhao, Dingjun Zhu, Jinli Han, Haicheng Chen, Yuhong Cai, Zhiliang Chen, Wenlian  Xie   +7 more
doaj   +1 more source

CD248 Expression in Clear Cell Renal Cell Carcinoma and Its Clinical Significance

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the expression of CD248 (endosialin) in clear cell renal cell carcinoma (ccRCC) tissues and its clinical significance. Methods We collected fresh specimens from 17 ccRCC tissues and adjacent tissues, as well as paraffin specimens
HU Wei, ZHU Hengcheng, LI Haoyong, LIU Xiuheng, ZENG Yan   +4 more
doaj   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

The prognostic significance of UBE3C expression in ccRCC.

, 2015
(A) Real-time quantitative RT-PCR analysis of UBE3C expression in ccRCC and corresponding peritumoral renal tissues. The relative expression of UBE3C mRNA in ccRCC tissue samples was higher than that in the paired peritumoral renal tissues.
Xiao Fei Wen (689906), Rong Bing Li (689907), Hui Xing Chen (689910), Ji Ling Wen (689905), Yong Chao Jin (689908), Xue Lei Wang (689909), Lan Zhou (407521)   +6 more
core   +1 more source

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Hyperpolarized MRI in Oncology—A Review of Clinical Studies and Evaluation of Preclinical Liver Studies

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Hyperpolarized MRI is a promising clinical imaging modality in oncology, offering at least nine imaging contrasts obtainable with hyperpolarized [1‐13C]pyruvate as the injected agent, depending on the tissue and condition under investigation. Preclinical studies suggest that hyperpolarized MRI is warranted for detecting hepatocellular carcinoma within ...
Naama Lev‐Cohain, Jacob Sosna, Rachel Katz‐Brull   +2 more
wiley   +1 more source