Results 41 to 50 of about 997 (101)

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

CCT7 indicates a poor prognosis and is associated with immune infiltration in colonic adenocarcinoma

Abstract Objective CCT7, a member of the t-complex polypeptide 1 chaperone family, facilitates protein folding in an ATP-dependent manner. To date, the role of CCT7 in the onset and progression of malignant tumors remains unclear.
Wenxu Li, Qizhong Shi, Yonghui Mu, Chenglei Li, Wenchao Zhao, Na Han   +5 more
openaire   +1 more source

Effects of maternal exercise modes on infant cord blood proteome

Physiological Reports, Volume 13, Issue 18, September 2025.
Abstract The aim of this study was to show the effects of different maternal exercise modes on infant cord blood proteome. We used infant cord blood from two randomized controlled trials where women with a wide range of BMI and free of pregnancy complications participated in controlled and supervised aerobic, resistance, or combination (aerobic ...
Filip Jevtovic, Breanna Wisseman, Fahmida Jahan, Alex Claiborne, David N. Collier, James E. DeVente, Steven Mouro, Tonya N. Zeczycki, Laurie J. Goodyear, Linda E. May   +9 more
wiley   +1 more source

A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study

Physiological Reports, Volume 13, Issue 12, June 2025.
Abstract Compared with 2D monolayers, 3D models more closely mimic native muscle tissue and allow functional measurements. A more complete understanding of how culture conditions and duration affect myotube maturity/function is crucial for validating the transition to 3D systems.
Benjamin R. Tollitt, Samantha W. Jones, Jessica Ohana, James R. Henstock, Malcolm J. Jackson, Anne McArdle   +5 more
wiley   +1 more source

Proteomic analysis to explore potential mechanism underlying pseudomale sperm defect in Cynoglossus semilaevis

Aquaculture Reports
Females of Chinese tongue sole (Cynoglossus semilaevis) grow 2–4 times faster and bigger than males, but some genetic females can sex reverse into phenotypic males (called pseudomales, ZW karyotype) that presents similar slow growth to normal males ...
Xihong Li, Lu Li, Zhongkai Cui, Ming Li, Xuexue Sun, Zhijie Li, Zhangfan Chen, Lanqing Ding, Dongdong Xu, Wenteng Xu   +9 more
doaj   +1 more source

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
EVs were isolated from plasma of ME/CFS patients and healthy controls at baseline, and 15 min and 24 h postexercise. Untargeted proteomics revealed dysregulation in energy metabolism, the complement system, and the endoplasmic reticulum stress response. Changes in EV protein levels postexercise are associated with post‐exertional malaise.
Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson   +3 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

TRIM38 Suppresses the Progression of Colorectal Cancer via Enhancing CCT6A Ubiquitination to Inhibit the MYC Pathway

Advanced Science, Volume 12, Issue 16, April 24, 2025.
This study reveals the tumor‐suppressive role of TRIM38 in colorectal cancer (CRC). TRIM38 is downregulated through DNA hypermethylation and correlates with unfavorable clinical features and poor prognosis. Mechanistically, TRIM38 inhibits CRC progression by promoting K48‐linked ubiquitination of CCT6A, leading to the destabilization of c‐Myc.
Yue Zhang, Xinyu Tan, Lu Wang, Dongjian Ji, Chuan Zhang, Wen Peng, Renzhong Zhu, Xiaowei Wang, Jiahui Zhou, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source