Results 31 to 40 of about 997 (101)

Differential Protein Expression in Striatal D1- and D2-Dopamine Receptor-Expressing Medium Spiny Neurons

Proteomes, 2020
Many neurological disorders and diseases including drug addiction are associated with specific neuronal cell types in the brain. The striatum, a region that plays a critically important role in the development of addictive drug-related behavior, provides
M. Shahid Mansuri, Gang Peng, Rashaun S. Wilson, TuKiet T. Lam, Hongyu Zhao, Kenneth R. Williams, Angus C. Nairn   +6 more
doaj   +1 more source

Lecithin Prevents Cortical Cytoskeleton Reorganization in Rat Soleus Muscle Fibers under Short-Term Gravitational Disuse. [PDF]

PLoS ONE, 2016
The aim of this study was to prevent the cortical cytoskeleton reorganization of rat soleus muscle fibers under short-term gravitational disuse. Once a day, we injected the right soleus muscle with 0.5 ml lecithin at a concentration of 200 mg/ml and the ...
Irina V Ogneva, Nikolay S Biryukov
doaj   +1 more source

Intron sequences from the CCT7 gene exhibit diverse evolutionary histories among the four lineages within the Babesia microti-group, a genetically related species complex that includes human pathogens.

Japanese journal of infectious diseases, 2011
Babesia microti, the primary causal agent of human babesiosis in North America, was thought to distribute in Europe in association with ixodid ticks and rodents. Recent analyses of β-tubulin and the eta subunit of the chaperonin-containing t-complex protein 1 (CCT7) genes revealed discrete clusters (a species-complex comprised of at least 4 taxa for ...
Fujisawa, Kohei, Nakajima, Rui, Jinnai, Michio, Hirata, Haruyuki, Zamoto-Niikura, Aya, Kawabuchi-Kurata, Takako, Arai, Satoru, Ishihara, Chiaki   +7 more
openaire   +3 more sources

CCT7 Expression Affects the Prognosis of Lung Adenocarcinoma

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background CCT7 is a chaperonin containing tailless complex polypeptide 1 subunit. The study focused on investigating its prognostic significance for lung adenocarcinoma (LUAD). Methods CCT7 expression in LUAD and matched non‐carcinoma lung samples was examined via TCGA database. Besides, we utilized the GEO database and RT‐qPCR for validating
Yue Li, Longqian Wei, Guiyu Feng, Guosheng Li, Jielin Ma, Xiang Gao, Jun Liu, Nuo Yang, Huafu Zhou   +8 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target

Aging Cell, Volume 25, Issue 3, March 2026.
By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Mingzhu Zhang, Ziqi Hu, Shengwen Piao, Yingrui Song, Ying Jia, Jiaxing Liu, Ning Zhao, An Liu, Songbin Fu, Wenjing Sun, Hui Xu, Yu Yang, Steven P. Gygi, Chunshui Zhou   +13 more
wiley   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, Volume 13, Issue 12, 27 February 2026.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis

Frontiers in Neurology
ObjectiveTo investigate the serum biomarkers in patients with drug-resistant epilepsy (DRE).MethodsA total of 9 DRE patients and 9 controls were enrolled.
Mian Ma, Ying Cheng, Xiaoxia Hou, Zhisen Li, Meixia Wang, Bodun Ma, Qingzhang Cheng, Zhiliang Ding, Hongxuan Feng   +8 more
doaj   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source