Results 11 to 20 of about 997 (101)

CCT7 Regulates TRAF6 ‐Mediated Autophagy to Promote Posttraumatic Joint Contracture

Journal of Cellular and Molecular Medicine
ABSTRACT Posttraumatic joint contracture (PTJC) is a prevalent complication of joint injury, characterised by marked reductions in both active and passive joint motion. Previous studies have indicated that the chaperonin‐containing T‐complex polypeptide (CCT) is involved in fibrotic processes. Thus, this study aims to explore the role
Yutai Li, Wenhui Zhang, Wenbin Xu, Yuliang Huang, Honghua Cai, Nanwei Zhang, Tangzhao Liang, Guihua Liu   +7 more
openaire   +2 more sources

Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex

Molecular Biology of the Cell, 2016
Mechanisms that prevent aggregation and promote folding of nascent G protein–coupled receptors (GPCRs) remain poorly understood. We identified chaperonin containing TCP-1 subunit eta (CCT7) as an interacting partner of the β-isoform of thromboxane A2receptor (TPβ) by yeast two-hybrid screening.
Samuel Genier, Jade Degrandmaison, Jean-Luc Parent   +2 more
exaly   +3 more sources

Correlating blood immune parameters and a CCT7 genetic variant with the shedding of Salmonella enterica serovar Typhimurium in swine

Veterinary Microbiology, 2009
The porcine response to Salmonella infection is critical for control of Salmonella fecal shedding and the establishment of Salmonella carrier status. In this study, 40 crossbred pigs were intranasally inoculated with Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) and monitored for Salmonella fecal shedding and blood immune parameters ...
Christopher K Tuggle
exaly   +5 more sources

Profile and diagnostic value of N6-methyladenosine-related mRNA regulators in colorectal adenoma and colorectal cancer [PDF]

BMC Gastroenterology
Background N6-methyladenosine (m6A) modification is a key epigenetic modification involved in many diseases. However, the roles of m6A regulators in the progression of colorectal adenoma (CRA) or colorectal cancer (CRC) are still unclear fully.
Wei Wang, Xiaohui Zhang, Min Wang, Li Wang, Shiqing Qian, Wenli Cheng, Fang Xu, Shaopeng Ding, Yuting Zhu, Guoqing Jin, Wanshui Yang, Anla Hu, Qihong Zhao   +12 more
doaj   +2 more sources

STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation [PDF]

Nature Communications
Tubulin-based microtubule is a core component of flagella axoneme and essential for sperm motility and male fertility. Structural components of the axoneme have been well explored.
Yu Chen, Mengjiao Luo, Haixia Tu, Yaling Qi, Yueshuai Guo, Xiangzheng Zhang, Yiqiang Cui, Mengmeng Gao, Xin Zhou, Tianyu Zhu, Hui Zhu, Chenghao Situ, Yan Li, Xuejiang Guo   +13 more
doaj   +2 more sources

Proteomic analysis illustrates the potential involvement of dysregulated ribosome-related pathways and disrupted metabolism during retinoic acid-induced cleft palate development [PDF]

BMC Medical Genomics
Recent studies have unveiled disrupted metabolism in the progression of cleft palate (CP), a congenital anomaly characterized by defective fusion of facial structures.
Wancong Zhang, Liyun Chen, Aiwei Ma, Wenshi Jiang, Mengjing Xu, Xujue Bai, Jianda Zhou, Shijie Tang   +7 more
doaj   +2 more sources

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex. [PDF]

Adv Sci (Weinh)
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Wang Z, Huang H, Huang K, Cui X, Wu L, Lin R, Zhao Z, Chen H, Zheng C, Jin W, Chen S, Chen J, Xu Y, Wei D.   +13 more
europepmc   +2 more sources

Proteomic identification of arginine-methylated proteins in colon cancer cells and comparison of messenger RNA expression between colorectal cancer and adjacent normal tissues [PDF]

Annals of Coloproctology, 2022
Purpose Identification of type I protein arginine methyltransferase (PRMT) substrates and their functional significance during tumorigenesis is becoming more important.
Yongchul Lim, Da Young Gang, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Hee Cheol Kim   +7 more
doaj   +1 more source

T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces murine teratospermia [PDF]

PeerJ, 2021
Background The CCT complex is an important mediator of microtubule assembly and intracellular protein folding. Owing to its high expression in spermatids, CCT knockdown can disrupt spermatogenesis.
Peiyin Yang, Wenjing Tang, Huiling Li, Rong Hua, Yan Yuan, Yue Zhang, Yunfei Zhu, Yiqiang Cui, Jiahao Sha   +8 more
doaj   +2 more sources

Ubiquitination-Driven Reprogramming of Proteostasis in Metastasis. [PDF]

Adv Sci (Weinh)
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Wei D, Chen J, Xu Y.
europepmc   +2 more sources