Chaperonin TRiC/CCT subunit CCT7 is involved in the replication of canine parvovirus in F81 cells [PDF]
Frontiers in MicrobiologyCanine parvovirus (CPV) is one of the most common lethal viruses in canines. The virus disease is prevalent throughout the year, with high morbidity and mortality rate, causing serious harm to dogs and the dog industry.
Xia Su, Hongzhuan Zhou, Fuzhou Xu
exaly +6 more sources
Requirement of Cellular Protein CCT7 for the Replication of Fowl Adenovirus Serotype 4 (FAdV-4) in Leghorn Male Hepatocellular Cells Via Interaction with the Viral Hexon Protein [PDF]
Viruses, 2019 Fowl adenovirus serotype 4 (FAdV-4) causes hepatitis-hydropericardium syndrome (HHS), leading to severe economic losses in the poultry industry. Although the pathogenesis of FAdV-4 infection has caused much attention, the underlying molecular mechanisms ...
Junfeng Gao +2 more
exaly +5 more sources
Inhibition of tau aggregation by the CCT3 and CCT7 apical domains [PDF]
Protein ScienceAbstractThe eukaryotic chaperonin containing t‐complex polypeptide 1 (CCT/TRiC) is a molecular chaperone that assists protein folding in an ATP‐driven manner. It consists of two stacked identical rings that are each made up of eight distinct subunits. Here, we show that the apical domains of subunits CCT3 and CCT7 from humans are strong inhibitors of ...
Nadav Elad +2 more
exaly +4 more sources
Chaperonin proteins CCT5 and CCT7 epigenetically restrict the transition from pluripotency to totipotency in embryonic stem cells [PDF]
Stem Cell ReportsAs members of the CCT family, CCT5 and CCT7 play pivotal roles in telomerase trafficking, with their depletion resulting in TCAB1 protein loss and impaired telomere maintenance. However, their functional significance in embryonic stem cells (ESCs) state transitions remains incompletely understood.
Jiang J +8 more
exaly +4 more sources
Polycomb Requires Chaperonin Containing TCP-1 Subunit 7 for Maintaining Gene Silencing in Drosophila [PDF]
Frontiers in Cell and Developmental Biology, 2021 In metazoans, heritable states of cell type-specific gene expression patterns linked with specialization of various cell types constitute transcriptional cellular memory.
Najma Shaheen +2 more
exaly +4 more sources
CCT7 predicts poor prognosis and correlates with immune infiltration in colonic adenocarcinoma [PDF]
Journal of Molecular HistologyNa Han, Li Wenxu, Han Na
exaly +4 more sources
Clinical Significance, Cellular Function, and Potential Molecular Pathways of CCT7 in Endometrial Cancer [PDF]
Frontiers in Oncology, 2020 Objective: Endometrial cancer (EC) is a common gynecologic malignancy; myometrial invasion (MI) is a typical approach of EC spreads and an important index to assess tumor metastasis and outcome in EC patients.
Liwen Wang +6 more
doaj +3 more sources
Frontiers in Oncology, 2021 [This retracts the article .].
Frontiers Editorial Office
doaj +3 more sources
Comprehensive Proteomic Profiling of Human Nav1.7-Interacting Proteins Reveals Conserved Regulatory Networks Involved in Nociceptive Signaling [PDF]
Neuroscience InsightsThe voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, is critically involved in the initiation and propagation of nociceptive signals. While prior research has delineated the interactome of mouse Nav1.7 (mNav1.7), the molecular partners ...
Xuelong Zhou, Jing Zhao
doaj +2 more sources
Unveiling the role of hexon-associated host proteins in fowl adenovirus serotype 4 replication [PDF]
Frontiers in Veterinary ScienceFowl adenovirus serotype 4 (FAdV-4), a member of the family Adenoviridae and the genus Aviadenovirus, is responsible for a significant number of emerging diseases that cause substantial economic losses in the poultry industry worldwide. The hexon protein
Xiaojun Zhang +4 more
doaj +2 more sources