Frontiers in Genetics, 2021 BackgroundChaperonin-containing TCP-1 (TRiC or CCT) was demonstrated to be involved in oncogenesis of cancers carcinogenesis and development of various malignancies.
Wen-Xiu Xu +6 more
doaj +1 more source
Analysis of CCT7 Expression and Its Clinical Significance in Endometrial Cancer [PDF]
, 2020 Abstract Objective: Endometrial cancer (EC) is a common gynecologic malignancy; myometrial invasion (MI) is a typical approach of EC spreads and an important index to assess tumor metastasis and outcome of EC patients. CCT7 is a member of the TCP1 chaperone family, involved in cytoskeletal protein folding and unfolding.
Liwen Wang +4 more
openaire +2 more sources
Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma
Frontiers in Genetics, 2021 Chaperonin containing TCP-1 (T-complex protein 1) (CCT) is a large molecular weight complex that contains nine subunits (TCP1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT6B, CCT7, CCT8). This study aimed to reveal key genes which encode CCT subunits for prognosis
Wenli Li, Jun Liu, Hetong Zhao
doaj +1 more source
Biomedicines, 2023 Polycystic ovary syndrome (PCOS) affects reproductive-age women. This condition causes infertility, insulin resistance, obesity, and heart difficulties. The molecular basis and mechanism of PCOS might potentially generate effective treatments.
Roozbeh Heidarzadehpilehrood +4 more
doaj +1 more source
CCT7 Regulates TRAF6 ‐Mediated Autophagy to Promote Posttraumatic Joint Contracture [PDF]
Journal of Cellular and Molecular MedicineWenbin Xu, Tangzhao Liang
exaly +1 more source
sGC Activity and Regulation of Blood Flow in a Zebrafish Model System
Frontiers in Physiology, 2021 Soluble guanylyl cyclase (sGC) protein is a heterodimer formed by two subunits encoded by GUCY1A1 and GUCY1B1 genes. The chromosomal locus 4q32.1 harbors both of these genes, which has been previously significantly associated with coronary artery disease,
Krishan K. Vishnolia +15 more
doaj +1 more source
Effect of Inulin on Proteome Changes Induced by Pathogenic Lipopolysaccharide in Human Colon. [PDF]
PLoS ONE, 2017 In the present study, the protective role of inulin against lipopolysaccharide (LPS)-induced oxidative stress was evaluated on human colonic mucosa using a proteomic approach.
Michele Pier Luca Guarino +14 more
doaj +1 more source
Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis. [PDF]
PLoS ONE, 2017 Aberrant nucleocytoplasmic localization of proteins has been implicated in many neurodegenerative diseases. Evidence suggests that cytoplasmic mislocalization of nuclear proteins such as transactive response DNA-binding protein 43 (TDP-43) and fused in ...
Jee-Eun Kim +9 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2019 Background Joint contracture is a fibrous disease characterized as joint capsule fibrosis that results in joint dysfunction and disability. The purpose of this study was to analyze the biological activities of chaperonin containing T-complex polypeptide (
Xiaoyou Yi +6 more
doaj +1 more source
Chaperonins in Hepatocellular Carcinoma: Unveiling Their Role in Tumor Proliferation and Immune Modulation Through Multiomics Analysis. [PDF]
Int J GenomicsBackground Chaperonins are crucial regulators of tumor biology by controlling the stability and function of oncogenic and tumor‐suppressor proteins, influencing various tumorigenic signaling pathways. Although chaperonins have been widely discussed in various cancers, including hepatocellular carcinoma (HCC), the complex mechanisms by which they ...
Wang SH +5 more
europepmc +2 more sources