Results 21 to 30 of about 51,555 (247)

Two classes of CD1 genes

European Journal of Immunology, 1989
AbstractHerein, we report the DNA sequence of two human CD1 genes, R2 and R3, distinct from those encoding the CD1a, ‐b and ‐c antigens. Both genes appear to have an exon/intron structure analogous to the previously analyzed CD1 genes and to be functional on the basis of their sequence.
Calabi F, Jarvis JM, Martin L, Milstein C   +3 more
openaire   +5 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F-actin distribution. [PDF]

FEBS Open Bio
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Joseph TV, Pham AB, Bornes KE, Hammad RH, Rousseve-Ross CA, Huckaba TM, Watt TJ, Toro TB.   +7 more
europepmc   +2 more sources

CD1 and mycobacterial lipids activate human T cells

Immunological Reviews, 2015
For decades, proteins were thought to be the sole or at least the dominant source of antigens for T cells. Studies in the 1990s demonstrated that CD1 proteins and mycobacterial lipids form specific targets of human αβ T cells.
Risk Assessment, dI&I RA-I&I I&I, LS Immunologie, Moody, D Branch, Infection & Immunity, Van Rhijn, Ildiko   +5 more
core   +1 more source

Molecular characterisation of Ovine CD1 [PDF]

, 1994
The CD1 molecules are a family of ß2microglobulin- associated glycoproteins with strong structural homology, but weaker sequence homology, to the MHC class I antigens. In contrast to the classical class I antigens, CD1 molecules exhibit restricted
Ferguson, Elaine Dorothea
core   +3 more sources

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver [PDF]

, 2007
CD1d-restricted natural killer T (NKT) cells expressing invariant Vα14Jα18 T cell receptor α-chains are abundant in murine liver and are implicated in the control of malignancy, infection and autoimmunity.
Hogan, Andrew E., Exley, Mark A., Margaret O’Brien, Steven A. Porcelli, Andrew E. Hogan, Tony Kenna, O’Brien, Margaret, Hogan, Andrew, Porcelli, Steven A., John E. Hegarty, Mark A. Exley, Cliona O’Farrelly, O’Farrelly, Cliona, Derek G. Doherty, O'Farrelly, Cliona, Hegarty, John E., Kenna, Tony, Doherty, Derek G., O'Brien, Margaret   +18 more
core   +1 more source

3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations

Frontiers in Physiology, 2020
Dysfunctions of kynurenine pathway of tryptophan metabolism (KPTM) are associated with multiple neuropathologies in vertebrates and invertebrates.
Aleksandr V. Zhuravlev, Oleg V. Vetrovoy, Oleg V. Vetrovoy, Polina N. Ivanova, Polina N. Ivanova, Elena V. Savvateeva-Popova   +5 more
doaj   +1 more source

CD1-The Pathology Perspective [PDF]

Veterinary Pathology, 2001
CD1 molecules are a family of cell surface-associated glycoproteins now recognized as having a role in antigen presentation. These glycoproteins are distinct from yet have some similarities to classical major histocompatibility complex class I and class II molecules.
openaire   +3 more sources

Role of Group 1 CD1-restricted T Cells in Infectious Disease

Frontiers in Immunology, 2015
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens ...
Sarah eSiddiqui, Lavanya eVisvabharathy, Chyung-Ru eWang   +2 more
doaj   +1 more source

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]

, 2014
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco, Locatelli, Franco, Giulia Casorati, Paul Jenö, Chengfeng Xia, Consonni, Michela, S. R. Gundimeda, P. Jeno, Daniela Montagna, C. Bonini, Alessandra Forcina, G. Casorati, Claudia de Lalla, Franco Locatelli, Sansano, Sebastiano, Bonini, Chiara, Piccolo, Francesco, Xia, Chengfeng, Z. Li, P. Dellabona, Garavaglia, Claudio, H. Gsellinger, F. Piccolo, de Lalla, Claudia, Paolo Dellabona, G. Ni, F. Ciceri, Gundimeda, S. Ramanjaneyulu, Heiko Gsellinger, Häussinger, Daniel, Daniel Häussinger, Scelfo, Andrea, L. Mori, C. Garavaglia, Gennaro De Libero, A. Bondanza, Michela Consonni, Sebastiano Sansano, A. Forcina, Ciceri, Fabio, Jenö, Paul, Fabio Ciceri, M. Lepore, Attilio Bondanza, Gsellinger, Heiko, De Libero, Gennaro, S. Sansano, Bondanza, Attilio, Casorati, Giulia, D. Haussinger, Marco Lepore, C. de Lalla, G. De Libero, M. Consonni, Guanghui Ni, Lucia Mori, Li, Zhiyuan, Zhiyuan Li, Montagna, Daniela, Forcina, Alessandra, Andrea Scelfo, Mori, Lucia, S. Ramanjaneyulu Gundimeda, Chiara Bonini, Claudio Garavaglia, A. Scelfo, Francesco Piccolo, Ni, Guanghui, C. Xia, Dellabona, Paolo   +69 more
core   +1 more source

The feline sacroiliac joint: An overview of its innervation and morphology. [PDF]

J Anat
The sacroiliac joint of the domestic cat was examined, with a focus on the innervation and morphology of its auricular surface. The study revealed that the last lumbar and the first sacral spinal nerves run within the dorsal sacroiliac ligament, a finding that was confirmed microscopically.
Klick AS, Grochow T, Kalusa M, Fietz SA, Mülling CKW, Röhrmann N.   +5 more
europepmc   +2 more sources