Results 21 to 30 of about 48,670 (240)

Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity

Neurobiology of Disease, 2008
G1-phase cyclin D1 (cD1) expression has been documented in post-mitotic neurons undergoing apoptosis, leading others to propose that attempted cell cycle re-entry may induce cell death.
Hajira B. Koeller, M. Elizabeth Ross, Sara B. Glickstein   +2 more
doaj   +1 more source

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver [PDF]

, 2007
CD1d-restricted natural killer T (NKT) cells expressing invariant Vα14Jα18 T cell receptor α-chains are abundant in murine liver and are implicated in the control of malignancy, infection and autoimmunity.
Hogan, Andrew E., Exley, Mark A., Margaret O’Brien, Steven A. Porcelli, Andrew E. Hogan, Tony Kenna, O’Brien, Margaret, Hogan, Andrew, Porcelli, Steven A., John E. Hegarty, Mark A. Exley, Cliona O’Farrelly, O’Farrelly, Cliona, Derek G. Doherty, O'Farrelly, Cliona, Hegarty, John E., Kenna, Tony, Doherty, Derek G., O'Brien, Margaret   +18 more
core   +1 more source

3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations

Frontiers in Physiology, 2020
Dysfunctions of kynurenine pathway of tryptophan metabolism (KPTM) are associated with multiple neuropathologies in vertebrates and invertebrates.
Aleksandr V. Zhuravlev, Oleg V. Vetrovoy, Oleg V. Vetrovoy, Polina N. Ivanova, Polina N. Ivanova, Elena V. Savvateeva-Popova   +5 more
doaj   +1 more source

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2 [PDF]

J Neuroendocrinol
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Martín‐Sánchez A, Jiménez‐Díaz D, Esteve‐Pérez R, Vasile‐Tudorache A, Read J, Howard S, Agustín‐Pavón C.   +6 more
europepmc   +2 more sources

Електричні та фотоелектричні властивості гетеропереходів МоOx/n-Cd1-хZnхTe

East European Journal of Physics, 2021
У роботі представлено результати досліджень оптичних і електричних властивостей напівпровідникових гетеропереходів МоOx/n-Cd1-хZnхTe виготовлених нанесенням плівок MoOx на попередньо поліровану поверхню пластин n-Cd1-хZnхTe (розміром 5 × 5 × 0,7 мм3) в ...
Mykhailo M. Solovan, Andrii I. Mostovyi, Hryhorii P. Parkhomenko, Viktor V. Brus, Pavlo D. Maryanchuk   +4 more
doaj   +1 more source

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]

, 2014
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco, Locatelli, Franco, Giulia Casorati, Paul Jenö, Chengfeng Xia, Consonni, Michela, S. R. Gundimeda, P. Jeno, Daniela Montagna, C. Bonini, Alessandra Forcina, G. Casorati, Claudia de Lalla, Franco Locatelli, Sansano, Sebastiano, Bonini, Chiara, Piccolo, Francesco, Xia, Chengfeng, Z. Li, P. Dellabona, Garavaglia, Claudio, H. Gsellinger, F. Piccolo, de Lalla, Claudia, Paolo Dellabona, G. Ni, F. Ciceri, Gundimeda, S. Ramanjaneyulu, Heiko Gsellinger, Häussinger, Daniel, Daniel Häussinger, Scelfo, Andrea, L. Mori, C. Garavaglia, Gennaro De Libero, A. Bondanza, Michela Consonni, Sebastiano Sansano, A. Forcina, Ciceri, Fabio, Jenö, Paul, Fabio Ciceri, M. Lepore, Attilio Bondanza, Gsellinger, Heiko, De Libero, Gennaro, S. Sansano, Bondanza, Attilio, Casorati, Giulia, D. Haussinger, Marco Lepore, C. de Lalla, G. De Libero, M. Consonni, Guanghui Ni, Lucia Mori, Li, Zhiyuan, Zhiyuan Li, Montagna, Daniela, Forcina, Alessandra, Andrea Scelfo, Mori, Lucia, S. Ramanjaneyulu Gundimeda, Chiara Bonini, Claudio Garavaglia, A. Scelfo, Francesco Piccolo, Ni, Guanghui, C. Xia, Dellabona, Paolo   +69 more
core   +1 more source

Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes

Clinical and Developmental Immunology, 2011
Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells.
Angelo Aquino, Grazia Graziani, Ornella Franzese, Salvatore P. Prete, Enzo Bonmassar, Laura Bonmassar, Stefania D'Atri   +6 more
doaj   +1 more source

CD1 displays its own negative regulators

, 2023
After two decades of the study of lipid antigens that activate CD1-restricted T cells, new studies show how autoreactive αβ T-cell receptors (TCRs) can directly recognize the outer surface of CD1 proteins in ways that are lipid-agnostic.
Adam Shahine, D. Branch Moody, Shahine, Adam, Jamie Rossjohn, Rossjohn, Jamie, Ildiko Van Rhijn, Moody, D. Branch, Van Rhijn, Ildiko   +7 more
core   +1 more source

Characterization of a Novel Alginate Lyase with Two Alginate Lyase Domains from the Marine Bacterium Vibrio sp. C42

Marine Drugs, 2022
Alginate is abundant in the cell walls of brown algae. Alginate lyases can degrade alginate, and thus play an important role in the marine carbon cycle and industrial production.
Xiao-Meng Sun, Zhao Xue, Mei-Ling Sun, Yi Zhang, Yu-Zhong Zhang, Hui-Hui Fu, Yu-Qiang Zhang, Peng Wang   +7 more
doaj   +1 more source

Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection.

PLoS Pathogens, 2020
Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have ...
Lavanya Visvabharathy, Samantha Genardi, Liang Cao, Ying He, Francis Alonzo, Evgeny Berdyshev, Chyung-Ru Wang   +6 more
doaj   +1 more source