Results 51 to 60 of about 31,883 (222)

89723 CD105-targeted CAR T cells for the treatment of acute myeloid leukemia

Journal of Clinical and Translational Science, 2021
IMPACT: Our work might lead to a new treatment for patients with acute myeloid leukemia OBJECTIVES/GOALS: Acute myeloid leukemia (AML) is a devastating hematologic malignancy, with dismal 5-year survival. Chimeric antigen receptor (CAR) T cells have been
Konstantinos Lontos, Yiyang Wang, Andrew Frisch, Mason Colbert, Jason Lohmueller, Greg M. Delgoffe   +5 more
doaj   +1 more source

Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features

Clinics
OBJECTIVE To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver.
Osmar Damasceno Ribeiro, Nathalie Henriques Silva Canedo, Vera Lucia Pannain   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Correlation between CD105 expression and postoperative recurrence and metastasis of hepatocellular carcinoma

BMC Cancer, 2006
Background Angiogenesis is one of the mechanisms most critical to the postoperative recurrence and metastasis of hepatocellular carcinoma (HCC). Thus, finding the molecular markers associated with angiogenesis may help identify patients at increased risk
Wang Wei, Huang Geng-wen, Lu Wei-qun, Yang Lian-yue   +3 more
doaj   +1 more source

CD105+CD90+CD13+ identifies a clonogenic subset of adventitial lung fibroblasts

Scientific Reports, 2021
Mesenchymal cells are important components of specified niches in the lung, and can mediate a wide range of processes including tissue regeneration and repair.
Måns Kadefors, Sara Rolandsson Enes, Emma Åhrman, Barbora Michaliková, Anna Löfdahl, Göran Dellgren, Stefan Scheding, Gunilla Westergren-Thorsson   +7 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome [PDF]

, 2005
Angiogenesis is essential for the development and progression of malignant tumours, and there is increasing evidence that microvessel density (MVD) can be considered an indirect marker of neo-angiogenesis.
G. Bellone, Paola Rosso, F. Fraire, Giorgio Cortesina, T. Martone, G. Pruneri, L. Pignataro, Giuseppe Migliaretti, Lorenzo Pignataro, Flavio Fraire, Tiziana Martone, Roberto Albera, G. Cortesina, R. Albera, Giancarlo Pruneri, G. Migliaretti, Graziella Bellone, P. Rosso   +17 more
core   +1 more source

Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer

Journal of Translational Medicine, 2004
Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in human cancer; however, a specific cell membrane marker for endothelial cells of tumor vasculature has not been discovered yet.
Maio Michele, Fonsatti Ester
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Endoglin (CD105) as a urinary and serum marker of prostate cancer [PDF]

International Journal of Cancer, 2008
AbstractWe have previously shown that endoglin (CD105) is upregulated in prostatic fluid of men with large volume prostate cancer. We chose to assess endoglin levels in urine and serum from men with prostate cancer or at increased risk for the disease: Urine samples were collected after digital rectal examination (DRE) from 99 men whose cancer status ...
Kazutoshi, Fujita, Charles M, Ewing, David Y S, Chan, Leslie A, Mangold, Alan W, Partin, William B, Isaacs, Christian P, Pavlovich   +6 more
openaire   +2 more sources