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CD123: A Novel Biomarker for Diagnosis and Treatment of Leukemia
Cardiovascular & Hematological Disorders-Drug Targets, 2019: Leukemia is a group of progressive hematologic malignancies derived from stem cells in bone marrow which causes a large number of cancer deaths. Even with treatment such as traditional chemotherapy, targeted therapy, and allogeneic stem cell transplantation (allo-HSCT), many patients suffer from relapse/refractory disease, and the overall survival ...
Mingyue, Shi +6 more
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Development of a novel engineered antibody targeting human CD123
Analytical Biochemistry, 2016Antibody engineering involves a range of custom modifications of immunoglobulins to improve their affinity, valency, and pharmacokinetics, ensuring a better target therapy achievement. A number of therapeutic antibodies have been used for cell surface receptor blockage, interfering with the ligand binding and inhibiting receptor-driven activation of ...
Shima, Moradi-Kalbolandi +7 more
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CD123 (Interleukin 3 receptor a chain).
2001CD 123 is the interleukin 3 receptor alpha chain and is expressed on different type of myloid hematopoietic ...
Moretti S. +6 more
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[Significance of CD123 in histiocytic necrotizing lymphadenitis].
Zhonghua bing li xue za zhi = Chinese journal of pathology, 2015To investigate the mode of presentation, cytologic features of the plasmacytoid dendritic cells (pDC), and the expression of CD123 and its significance in Kikuchi's disease.CD123 expression was evaluated by EliVision immunohistochemical staining in formalin-fixed and paraffin-embedded tissues from 30 cases of Kikuchi's disease, 5 cases of T cell ...
Xuejing, Wei +4 more
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Targeting CD123 in hematologic malignancies: identifying suitable patients for targeted therapy
Leukemia and Lymphoma, 2021Mrinal M Patnaik +2 more
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Immunotherapies Targeting CD123 for Blastic Plasmacytoid Dendritic Cell Neoplasm
Hematology/Oncology Clinics of North America, 2020L Elizabeth Budde
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