Results 31 to 40 of about 14,385 (213)

CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides

, 2021
Introduction: CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous. Aim: To determine the significance of the CD123 immunostain, which labels plasmacytoid dendritic cells (PDC), in cutaneous lupus ...
Büyücek, Şeyma, Coşkun, Sinem, Gamsızkan, Mehmet, Karagün, Ebru, Seyma Buyucek, Ebru Karagun, Mehmet Gamsizkan, Sinem Coskun   +7 more
core   +1 more source

Expression and significance of dendritic cell markers CD123, FXⅢA and CD1a in leprosy lesions

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the role of dendritic cells in the pathogenesis of leprosy. Method: The expression of three dendritic cell markers (CD123, FXⅢA, CD1a) in leprosy lesions was assessed by immunohistochemical staining, and their significance was ...
Wenjun ZHOU, Yan QIN
doaj   +1 more source

Development of Astatine-211 ( 211 At)-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ Hematologic Malignancies

, 2021
Background: Radioimmunotherapy (RIT) has long been pursued to improve outcomes in acute leukemia. Of current interest are alpha-particle emitting radionuclides as they deliver a very large amount of radiation over just a few cell diameters, enabling ...
Walter, Roland B., Orozco, Johnnie J., Wilbur, D. Scott, Green, Damian J., Lunn, Margaret C., Dexter, Shannon L., Hamlin, Donald K., O'Steen, Shyril, Laszlo, George S., Kehret, Allie R., Comstock, Melissa C., Margaret C. Lunn, Donald K. Hamlin, Damian J. Green, Allie R. Kehret, Shyril O'Steen, George S. Laszlo, Melissa C. Comstock, Roland B. Walter, Shannon L. Dexter, D. Scott Wilbur, Johnnie J. Orozco   +21 more
core   +1 more source

Study of CD123 (interleukin-3 receptor alpha Chain) and nuclear factor kappa B in adult acute myeloid leukemia patients

Journal of Applied Hematology, 2014
Background: The genomic alterations in acute myeloid leukemia (AML) affect the function of signaling molecules, transcription factors, and growth factor receptors besides they influence the response to treatment. Interleukin-3 receptor alpha chain (CD123)
Inas Asfour, Soha Yoyssef, Maryse Ayoub, Nevine Moustafa, Hani Ayash, Tussneem Elhassan, Ghada M ElGohary   +6 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

IMMUNOPHENOTYPIC COMPARISON BETWEEN REACTIVE BONE MARROW B-LYMPHOCYTE PRECURSOR (HEMATOGONES) AND B-NEOPLASTIC LYMPHOBLAST LEUKAEMIA USING CD 34, CD 123 BY FLOWCYTOMETRY

The Iraqi Journal of Medical Sciences, 2016
Background:Flow cytometric study found that lymphoblasts of B acute lymphoblastic leukemia exhibited multiple aberrant antigens by which they can be distinguished from hematogones. These antigens are CD34 and CD123.
Yousra A. Shallan, Raad J. Musa
doaj   +4 more sources

Discoid Lupus Erythematosus in Genital Skin: A Case Report and Review of the Literature. [PDF]

J Cutan Pathol
ABSTRACT Background Discoid lupus erythematosus (DLE) represents the most common variant of chronic cutaneous lupus erythematosus, a skin‐specific autoimmune disorder within the broader lupus erythematosus spectrum Clinically, DLE is characterized by erythematous, scaly plaques with areas of hyperpigmentation.
Abu-Dayeh A, Miller D, Giubellino A.
europepmc   +2 more sources

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia [PDF]

, 2021
Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell persistence.
Hein, Lutz; https://orcid.org/, Zeiser, Robert; https://orcid.org/, Manz, Markus G; https://orcid.org/, Clarson, Jade, Yu, Wenbo, Vinnakota, Janaki Manoja, Hughes, Amy, Duyster, Justus, Myburgh, Renier, Hughes, Timothy P, Yong, Agnes S M; https://orcid.org/, Taromi, Sanaz; https://orcid.org/, Shoumariyeh, Khalid, El Khawanky, Nadia, Matschulla, Tony; https://orcid.org/, Miething, Cornelius; https://orcid.org/, Lopez, Angel F, Aumann, Konrad, Brown, Michael P; https://orcid.org/, White, Deborah L   +19 more
core   +1 more source

Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia

Journal for ImmunoTherapy of Cancer, 2023
The treatment of B cell malignancies has dramatically changed with the introduction of immunotherapy, especially chimeric antigen receptor T (CAR-T) cell therapy. However, only limited efficacy is observed in acute myeloid leukaemia (AML).
Ting Yang, Jingjing Wen, Yanxin Chen, Jiajie Yang, Chunye Dai, Shenjie Yu, Wenting Zhong, Lilin Liu, Chengguanng He, Wenmin Zhang, Lingfeng Liu, Jianda Hu   +11 more
doaj   +1 more source