Results 71 to 80 of about 5,434 (169)

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling

Cell Communication and Signaling
Objective The CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer immunotherapy.
Mingyao Huang, Xiaoqin Yu, Qing Wang, Zirong Jiang, Xiaofen Li, Wei Chen, Chuangui Song   +6 more
doaj   +1 more source

Prognostic significance of CD155 mRNA expression in soft tissue sarcomas

Oncology Letters, 2013
CD155 was initially identified as a receptor for poliovirus. Several studies have demonstrated that CD155 overexpression in cancer cells is significant in their migration, invasion, proliferation and metastasis. The objective of the present study was to investigate the correlation between CD155 expression and the clinical aggressiveness of soft tissue ...
ATSUMI, SATORU, MATSUMINE, AKIHIKO, TOYODA, HIDEMI, NIIMI, RUI, IINO, TAKAHIRO, SUDO, AKIHIRO   +5 more
openaire   +3 more sources

CD155/CD96 promotes immunosuppression in lung adenocarcinoma (LUAD) [PDF]

, 2019
Abstract Lung adenocarcinoma (LUAD) remains one of the leading causes of death in patients with cancer. The association of CD155 with CD96 transmits an inhibitory signal and suppresses antitumor immune response. This study investigates the effect of CD155/CD96 on immune suppression in LUAD.
He, Weiling, Zhang, Hui, Li, Shuhua, Cui, Yongmei, Zhu, Ying, Zhu, Junfeng, Lei, Yiyan, Lin, Run, Xu, Di, Zhu, Zheng, Jiang, Wenting, Wang, Han, Ke, Zunfu   +12 more
openaire   +1 more source

Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and the CD155/TIGIT Pathway. [PDF]

Mol Cancer Ther
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the deadliest major cancer and has a profoundly immunosuppressive tumor microenvironment (TME). Previous studies have shown that inhibition of the E1 enzyme, which catalyzes the small ubiquitin-like modifiers (SUMO), with the small molecule TAK-981, can reprogram the TME to enhance ...
De la Torre Medina J, Joshi U, Sonowal H, Kuang Y, Ren T, Chen DH, Tharuka MDN, Nguyen-Ta K, Gros HL, Mikulski Z, Chen Y, White RR.   +11 more
europepmc   +4 more sources

Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis

Cellular & Molecular Biology Letters
Background Osteosarcoma is the most prevalent primary malignant bone tumor affecting pediatric and adolescent individuals. However, despite the passage of three decades, there has been no notable enhancement in the overall survival rate of patients with ...
Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie, Tiao Lin   +12 more
doaj   +1 more source

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion

Journal for ImmunoTherapy of Cancer
Background Heat shock protein 47 (HSP47) is crucial for protein quality control and tumor progression. While its role in cancer biology is well established, its impact on cancer immunity remains poorly understood.
Liang Chen, Hao Zhou, Jiahao Zhang, Yucheng Xue, Wenkan Zhang, Zenan Wang, Hangxiang Sun, Binghao Li, Zhaoming Ye, Haochen Mou, Hao Qu, Shixin Chen, Zhuli Wang, Yinwang Eloy, Zhenxuan Shao, Fangqian Wang, Xupeng Chai, Minjun Yao, Shenzhi Zhao, Jiangchu Lei, Lingxiao Jin, Senxu Lu   +21 more
doaj   +1 more source

Abstracts of 14th International Symposium on Hodgkin Lymphoma

HemaSphere, Volume 10, Issue S2, October 2026.
wiley   +1 more source

Potential Roles of Serum Exosomal CD155 and its Impact on NK Cell Immunosuppression in Hepatocellular Carcinoma

Balkan Medical Journal
Background: Targeted therapies directed at tumor immune checkpoint, like programmed death-ligand (PD-L)1/programmed death (PD)-1, have shown remarkable progress.
Wenzheng Han, Jinrong Lv, Mintuo Wang, Xiaoxin Wu, Dongdong Sun, Wenwen Chen, Yingying Wang, Wenjie Zhou, Yuxuan Yang, Jia Bao, Qingzhen Han, Xiaopeng Chen, Fei Guo, Gang Feng, Min Li, Qing Chen   +15 more
doaj   +1 more source

Arecoline upregulates CD155 expression to facilitate immune evasion in oral squamous cell carcinoma

Journal for ImmunoTherapy of Cancer
Background Areca nut is the fourth most addictive substance worldwide and is a known Group 1 carcinogen. Chronic areca nut chewing has been strongly associated with the development of oral squamous cell carcinoma (OSCC), although the underlying ...
Qian Wang, Ming Zhou, Bo Xiang, Wei Xiong, Pan Chen, Zhaoyang Zeng, Shanshan Zhang, Junshang Ge, Yi Meng, Yuhang Liu, Yian Wang, Zhaojian Gong   +11 more
doaj   +1 more source