Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets [PDF]
BMC Genomics, 2009 Human peripheral blood monocytes (Mo) consist of subsets distinguished by expression of CD16 (FCgammaRIII) and chemokine receptors. Classical CD16- Mo express CCR2 and migrate in response to CCL2, while a minor CD16+ Mo subset expresses CD16 and CX3CR1 and migrates into tissues expressing CX3CL1.
Ancuta, Petronela +6 more
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Human CD16+ and CD16– monocyte subsets display unique effector properties in inflammatory conditions in vivo [PDF]
Journal of Leukocyte Biology, 2011 ABSTRACTTwo major subsets of human Mo are identified based on CD14 and CD16 expression: the classical CD16– Mo and the minor CD14+CD16+ Mo. In vitro studies suggested distinct function and differentiation potential for each cell population. However, the in vivo relevance of these findings remains unclear.
Sergio R, Aguilar-Ruiz +8 more
openaire +3 more sources
CD14 and CD16 expression in noninfectious granulomatous skin diseases
Journal of Cutaneous Immunology and Allergy, 2020 Objectives Peripheral blood monocytes are categorized as classical (CD14++/CD16−) or nonclassical (CD14−/CD16+ and CD14+/CD16+) based on their CD14 expression and CD16 expression. Maturation of classical monocytes produces CD14+/CD16+ macrophages.
Yuta Ito +4 more
doaj +2 more sources
Phenotype and functions of human dendritic cells derived from CD14+ monocyte subsets opposed to CD16 expression [PDF]
Бюллетень сибирской медицины, 2019 The aim of the study was to analyze the relationship between monocyte subpopulations and phenotype/ functions of monocyte-derived dendritic cells (DCs), as well as DC sensitivity to the tolerogenic effect of dexamethasone.Materials and methods. The study
E. R. Chernykh +7 more
doaj +2 more sources
TGFβ Is Specifically Upregulated on Circulating CD14++ CD16+ and CD14+ CD16++ Monocytes in Patients with Atrial Fibrillation and Severe Atrial Fibrosis [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Fibrotic remodeling of the atria plays a key role in the pathogenesis of atrial fibrillation (AF). As little is known about the contribution of circulating monocytes in atrial remodeling and the pathophysiology of AF, we investigated ...
David Heinzmann +6 more
doaj +2 more sources
Classical monocytes from patients with pancreatic ductal adenocarcinoma exhibit a significantly altered transcriptome profile compared with healthy volunteers [PDF]
, 2014 The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorPancreatic Ductal Adenocarcinoma (PDAC) affects approximately 8000 people every ...
Cook, Jenny Anne
core +4 more sources
Blood monocyte subtypes in patients with pulmonary tuberculosis infection
Al-Azhar Assiut Medical Journal, 2022 Background and aim Monocytes are the primary target for Mycobacterium tuberculosis infection. Important alterations in the proportions of circulating monocyte subpopulations were found in patients with active tuberculosis (aTB).
Tamer G El-Rab Attia +3 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 The third outbreak of coronavirus (CoV) infection (after SARS-CoV and MERS-CoV) caused by a novel CoV (SARS-CoV-2) of the genus Beta-coronavirus has become a global pandemic.
Abdolkarim Sheikhi +1 more
doaj +1 more source
Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response
OncoImmunology, 2021 The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga +15 more
doaj +1 more source
Quantitative whole-cell MALDI-TOF MS fingerprints distinguishes human monocyte sub-populations activated by distinct microbial ligands [PDF]
, 2015 Conventionally, human monocyte sub-populations are classified according to surface marker expression into classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)) and non-classical (CD14(+)CD16(++)) lineages. The involvement of non-classical monocytes,
Brunisholz, René +11 more
core +1 more source