Results 111 to 120 of about 113,609 (263)

Age‐Associated B Cells Contribute to Inflammation Via Antibody‐Independent Mechanisms in Takayasu Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang, Xiaoxi Yang, Xiaochuan Sun, Shangyi Jin, Lihong Du, Jinwei Gao, Jing Li, Zhen Chen, Yuexin Chen, Mengtao Li, Xinping Tian   +10 more
wiley   +1 more source

CD19-negative relapse with an apparent cytogenetic shift after blinatumomab-induced measurable residual disease clearance in Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. [PDF]

Leuk Res Rep
Saburi M, Nagano R, Maruyama R, Sakata M, Takata H, Ohtsuka E.   +5 more
europepmc   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Truncated CD19 as a selection marker for the isolation of stem cell-derived β-cells

Disease Models & Mechanisms
Luo Ting Huang, Raymond Jun-rui Gao, Dahai Zhang, Cuilan Nian, Willem Martzke, A. M. James Shapiro, Tatsuya Kin, Yaser Tahamtani, Francis C. Lynn   +8 more
doaj   +1 more source

DP028 | CD19.CAR-T CELL-DERIVED EXTRACELLULAR VESICLES RETAIN CAR EXPRESSION AND EXHIBIT CYTOTOXIC ACTIVITY AGAINST LEUKEMIC CELLS, SUPPORTING THEIR ROLE IN ANTITUMOR THERAPY.

Haematologica
CAR-T cell therapy has revolutionized the treatment of hematologic malignancies. Nevertheless, significant challenges remain, particularly concerning its severe adverse effects. Extracellular vesicles (EVs) emerged as promising therapeutic agents due to
P. Lanuti, F. Guardalupi, G. Corradi, R. Florio, D. Brocco, S. Veschi, E. Pennese, D. De Bellis, F. D’ascanio, A. Piro, L. De Lellis, P. Simeone, M. C. Cufaro, S. Pilato, I. D’amario, I. Villanova, B. Di Francesco, L. Di Re, F. Verginelli, D. Pieragostino, P. Salutari, F. Colasante, A. Natale, M. V. Mattioli, A. Fontana, R. Giancola, B. Fabi, S. Baldoni, S. Santarone, F. Restuccia, N. Tinari, P. Del Boccio, A. Cama, M. Di Ianni   +33 more
doaj  

Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy. [PDF]

Front Immunol
Scholz L, Hoymann N, Alboradi S, Grabar V, Uehre GM, Toth G, Mészáros J, Gennari P, Tchaikovski S, Ignatov A, Busse M.   +10 more
europepmc   +1 more source

CD19 Gene [PDF]

, 2020
openaire   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy. [PDF]

Sci Adv
Guo T, Zhu Z, Qu Y, Yu X, Zhu L, Wang Y, Liu K, Cui J, Dong X, Yoon CW, Kilic CY, He P, Gou S, Zeng Y, Datta P, Zhou Q, Xu H, Puri IK, Liu L, Shen K, Wang Y.   +20 more
europepmc   +1 more source

CD19 Positive [PDF]

, 2020
openaire   +1 more source