Results 181 to 190 of about 177,018 (304)

Long-term outcomes of co-administration of CD19 and CD22 CAR-T cell therapy in pediatric patients with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. [PDF]

Front Med (Lausanne)
Zhou Z, Wang T, Shi W, Wan X, Li W, Li Y, Yang J, Yang X, Yang L, Zhang J, Su M, An K, Wang X, Zhu H, Luo C, Lu J, Chen J, Song L, Tang Y, Li B.   +19 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Integrated Bioinformatics and Experimental Validation of Inflammatory Cytokine-Related Hub Genes in Pediatric Asthma. [PDF]

J Asthma Allergy
Gao MM, Wang X, Yin L, Wei XY, Li F.
europepmc   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

A distinct TCR⁺CD19⁺ population in the peritoneal cavity: B1a cells as precursors of extrathymic T cells. [PDF]

iScience
Yee SM, Seon JE, Seo JE, Seo HJ, Seo JH, Moon SH, Koo HS, Choi HR, Kim SM, Kang HS.   +9 more
europepmc   +1 more source

Dissecting the Influence of Batch Effects on Immunomics Pattern Discovery in High‐Dimensional Mass Cytometry

Cytometry Part A, EarlyView.
ABSTRACT High‐dimensional cytometry, such as mass cytometry (CyTOF), measures protein expression in single cells. When paired with AI‐enhanced data analytics, it facilitates the discovery of immune biomarkers that can assist in diagnosing and treating immune‐related diseases. However, fluctuating instrument readouts, known as batch effects, can obscure
Martin Wasser, Joo Guan Yeo, Valerie Chew, Jing Yao Leong, Salvatore Albani   +4 more
wiley   +1 more source

Tumor-associated CD19⁺ macrophages induce immunosuppressive microenvironment in hepatocellular carcinoma. [PDF]

Nat Commun
Wang J, Cao W, Huang J, Zhou Y, Zheng R, Lou Y, Yang J, Yan J, Tang J, Ye M, Hong Z, Wu J, Ding H, Zhang Y, Sheng J, Lu X, Xu P, Lu X, Bai X, Liang T, Zhang Q.   +20 more
europepmc   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Zamtocabtagene autoleucel: dual CD20-CD19 targeting for NHL. [PDF]

Blood Adv
Srinagesh HK, Muffly LS.
europepmc   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source