Results 171 to 180 of about 134,446 (292)

RHOA Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant Large B-cell Lymphomas. [PDF]

Blood Cancer Discov
Newsam AD, Ziccheddu B, Youssfi AA, Venkatarame Gowda Saralamma V, Foos-Russ S, Tsai DE, Sheffield-Veney I, Jeevan A, Manara P, Goretsky YE, Suissa DM, Russo MV, Fattakhov N, Carmona-Berrio D, Campos Gallego N, Coughlin CA, Sondhi AK, Roberts ER, Spiegel JY, Alderuccio JP, Amador C, Bilbao D, Coffey DG, Jain MD, Maura F, Locke FL, Schatz JH.   +26 more
europepmc   +1 more source

Safety and Metabolic Effects of Withania somnifera Seed Extract and Powder in Rats: Insights From DPP‐4 Molecular Docking

Food Safety and Health, EarlyView.
Withania somnifera seed extract and powder improved metabolic parameters in rats, particularly at higher extract doses, without evident hepatic, renal, hematological, or histopathological toxicity. Molecular docking further predicted strong DPP‐4 inhibitory potential of withanone, supporting the antidiabetic potential of W. somnifera seeds.
Muhammad Usman Khalid, Muhammad Waqar, Muhammad Tauseef Sultan, Muhammad Maaz, Ahmad Mujtaba Noman, Hassan Raza, Muhammad Israr, Djilali Benabdelmoumene, Abdifetah Ibrahim Omar   +8 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Transcriptomics distinguishes CD19- and CD19+ bone marrow plasma cells.

We used transcriptomics to delineate the gene expression signatures of the CD19- and CD19+ bone marrow plasma cell fractions. We demonstrate here that CD19+ bone marrow plasma cells express the gene hematopoietic cell signal transducer (HCST) and the switching B cell complex subunit SWAP70.   
openaire   +3 more sources

Comparative clinical outcomes and single-cell profiling of CD19 CAR-T versus blinatumomab for relapsed/refractory B-ALL. [PDF]

J Immunother Cancer
Wang K, Yu L, Liang X, Song F, Jiang S, Han S, Zhang M, Liu K, Wen R, Jin L, Xiong Y, Qiu Y, Xu H, Wei G, Wang D, Hu Y, Huang H.   +16 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Beyond CAR-T: Preventing and Treating Relapse in B-Cell Haematological Malignancies. [PDF]

Cells
Canichella M, Abruzzese E, Cefalo M, Gianfelici V, Mazzone C, Trotta GE, Laureana R, Cupelli L, Del Principe MI.   +8 more
europepmc   +1 more source

Flow Cytometry‐Guided Diagnosis of Cortical T‐Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background T‐cell lymphoblastic lymphoma (T‐LBL) and T‐cell acute lymphoblastic leukemia (T‐ALL) are considered a single biological entity, distinguished primarily by the extent of bone marrow infiltration. This distinction becomes diagnostically challenging in patients with borderline marrow blast counts and predominantly extramedullary ...
Chen Glait‐Santar, Yakir Moshe, Itzhaki‐Alfia Ayelet, Ben‐Zion Katz   +3 more
wiley   +1 more source

Reshaping the landscape of HLA desensitization through immune engineering. [PDF]

Transpl Int
Kervella D, Bestard O.
europepmc   +1 more source

Mertk drives alveolar bone loss in experimental periodontitis associated with altered neutrophil function and osteoclast recruitment

Journal of Periodontology, EarlyView.
Abstract Background Alveolar bone loss is the hallmark of periodontitis and often remains refractory to conventional mechanical and antimicrobial therapies in chronic cases. Mer receptor tyrosine kinase (Mertk) has been implicated in bone homeostasis, yet the immune mechanisms by which Mertk modulates periodontal bone resorption remain insufficiently ...
Nicholas Mazzara, Kesley Martin, Rana Dabaja, Justin Redmond, Victoria Maglaras, Maxwell Mianecki, Harout Ashekian, Joseph T. Decker, Ann M. Decker   +8 more
wiley   +1 more source