Results 151 to 160 of about 134,446 (292)

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana   +3 more
wiley   +1 more source

HLH-like syndromes associate with increased risk of death and CD19- relapse after CAR T in pediatric B-ALL. [PDF]

open access: yesBlood Adv
McNerney KO   +33 more
europepmc   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde   +5 more
wiley   +1 more source

Circulating tumor plasma cells quantification in newly diagnosed transplant ineligible real world multiple myeloma patients: Comparison of single‐platform flow cytometry versus next generation flow

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating tumor plasma cells (CTCs) at diagnosis are independent prognostic markers in newly diagnosed multiple myeloma (NDMM). Flow cytometry (FC) enables sensitive and cost‐effective CTC quantification, but prognostic cut‐offs vary across studies.
Elona Saraci   +30 more
wiley   +1 more source

CAR T cells for HLA desensitization: a new era in kidney transplantation. [PDF]

open access: yesSignal Transduct Target Ther
Mertens PR, Feist E, Mougiakakos D.
europepmc   +1 more source

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