Results 141 to 150 of about 113,609 (263)

Salvage Therapy With Inotuzumab Ozogamicin in Relapsed/Refractory B-ALL After CAR-T Therapy and HSCT: A Case Series. [PDF]

Cancer Rep (Hoboken)
Li H, Yang L, Liu L, Lai X, Zhu L, Zhao K, Luo Q, Huang H, Luo Y.   +8 more
europepmc   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Immunotherapy of diffuse large B-cell lymphoma: from monoclonal antibodies to cellular therapies. A narrative review. [PDF]

Front Immunol
Aureli A, Lanzilli G, Boccadamo Pompili SV, Spagnoli GC, Sconocchia G, Caratelli S.   +5 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

IgA nephropathy-associated breast milk B cell alterations. [PDF]

Front Immunol
Zachova K, Cutkova A, Kosztyu P, Ohyama Y, Takahashi K, Zadrazil J, Orsag J, Petejova N, Mestecky J, Raska M.   +9 more
europepmc   +1 more source

Dietary fiber‐based oral nanovaccine promotes gut‐to‐nose trafficking of regulatory cells and drives antigen‐specific tolerance to relieve airway allergy

iMeta, EarlyView.
Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen‐specific immune tolerance. Here, we developed an oral nano‐dietary fiber (NDF) platform that integrates allergen delivery with microbiota‐driven immunomodulation, using dextran as both an antigen carrier and a fermentable substrate for ...
Yuting Qin, Zeming Wang, Yuru Zong, Zefang Lu, Junxiu Liu, Ruifang Zhao, Guangjun Nie, Hanqing Chen   +7 more
wiley   +1 more source

Single‐cell profiling of peripheral blood reveals acute‐phase immune dysregulation in human scrub typhus

iMeta, EarlyView.
Integrated single‐cell RNA sequencing, spectral flow cytometry, immune‐receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus. Patients exhibited expansion of cytotoxic, clonally amplified CD8+ T cells with exhaustion‐associated features, depletion and apoptosis of CD4+ T cells ...
Yijia Guo, Yi Niu, Nihui Zhang, Xiao Han, Liyuan Zhang, Yongguo Du, Lifen Han, Xiuying Tian, Zhao Xu, Gaoyu Wang, Kwok‐Yung Yuen, Jasper Fuk‐Woo Chan, Dahua Xu, Feifei Yin   +13 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Transcriptomics distinguishes CD19- and CD19+ bone marrow plasma cells.

We used transcriptomics to delineate the gene expression signatures of the CD19- and CD19+ bone marrow plasma cell fractions. We demonstrate here that CD19+ bone marrow plasma cells express the gene hematopoietic cell signal transducer (HCST) and the switching B cell complex subunit SWAP70.   
openaire   +3 more sources

A versatile and GMP-compliant bead-based IFN-γ potency assay for standardized quality control and release testing of CAR-T cell drug products. [PDF]

Int J Pharm X
Dennebos R, González-Corrales M, Lysandrou M, Smit NAM, Qi Y, van Meerten T, Kosterink JGW, Huls G, Lourens HJ, Gareb B, Bremer E.   +10 more
europepmc   +1 more source