Results 161 to 170 of about 126,758 (293)

B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression. [PDF]

Mol Biomed
Zhang Z, Yang N, Zeng H, Chen Y, Lu H, Xu L, Wang Z, Wang G, Zhou L, Tong A.   +9 more
europepmc   +1 more source

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Regulatory challenges of personalized medicine in the real world: are the right patients being treated with CD19-targeting CAR T-cells? [PDF]

EMBO Mol Med
Sebe A, Hernani R, Müller-Berghaus J.
europepmc   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, EarlyView.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

27‐color flow cytometry for measurable residual disease detection in B‐cell lymphoblastic leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Ryan C. Shean, Patricia Davis, Jeffery Jacobsen, David P. Ng   +3 more
wiley   +1 more source

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

Human CART22.19 therapy in refractory pediatric B-ALL: insights from a named-patient cohort. [PDF]

J Immunother Cancer
Mast AS, Lang P, Schlegel P, Calkoen FG, Atar D, Scheuermann S, Klein S, Braun C, Schinle F, Schmidt M, Hensen L, Ebinger M, Döring M, Schäfer JF, Schulte J, Bethge WA, Lengerke C, Alahmari B, Hu P, Schneider D, Orentas RJ, Handgretinger R, Seitz CM.   +22 more
europepmc   +1 more source

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

APOBEC2 deficiency disrupts hematopoietic lineage commitment, resulting in emergence of dual identity lymphocytes in mice and humans. [PDF]

Proc Natl Acad Sci U S A
Moris Amro E, Gkougkousis C, Seebass JG, Telioglu I, Bakr A, Lorenzo JP, Abolhassani H, Altenhofen J, Berntson L, Ruf S, Hammarström L, Pan-Hammarström Q, Imbusch CD, Papavasiliou FN.   +13 more
europepmc   +1 more source

A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform

Macromolecular Rapid Communications, EarlyView.
Randomized PEG (rPEG), a conceptually new PEG alternative, is combined with poly(2‐phenyl‐2‐oxazine) (PPheOzi) to establish an rPEG‐b‐PPheOzi‐b‐rPEG micellar drug delivery platform. The PPheOzi block enables high drug loadings, while competitive ELISA reveals a drastic reduction in anti‐PEG antibody affinity of rPEG in comparison to PEG.
Julian Schmidt, Anna‐Lena Ziegler, Florian T. Kaps, Laura J. Rosenberger, Matthias Bros, Holger Frey, Robert Luxenhofer   +6 more
wiley   +1 more source