Results 171 to 180 of about 13,147 (200)

Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice

The Journal of Immunology, 2022
Abstract CD1d, a lipid Ag-presenting molecule for invariant NKT (iNKT) cells, is abundantly expressed on adipocytes and regulates adipose homeostasis through iNKT cells. CD1d gene expression was restored in visceral adipose tissue adipocytes of CD1d knockout (KO) mice to investigate the interactions between adipocytes and immune cells ...
Run Xiao, Anthony G Mansour, Wei Huang, Quais N Hassan, Ryan K Wilkins, Suraj V Komatineni, Rhiannon Bates, Seemaab Ali, Logan A Chrislip, Nicholas J Queen, Shoubao Ma, Jianhua Yu, Matthew R Lordo, Bethany L Mundy-Bosse, Michael A Caligiuri, Lei Cao   +15 more
openaire   +2 more sources

The yin and yang of CD1d recognition

Nature Immunology, 2012
Structural studies identify considerable differences in the recognition of CD1d-lipid complexes by the TCRs of type II and type I (invariant) natural killer T cells.
Erin J Adams, Adrienne M Luoma
openaire   +1 more source

Roles of CD1d-restricted NKT cells in the intestine

Inflammatory Bowel Diseases, 2007
Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel diseases (IBD).
Dieren, Jolanda, van der Woude, C.J., Kuipers, Ernst, Escher, Hankje, Samsom, Janneke, Blumberg, RS, Nieuwenhuis, EES   +6 more
openaire   +3 more sources

The role of CD1d transmembrane and cytoplasmic tail domain in CD1d trafficking pathway

2015
CD1 molecules are a family of MHC class I-like lipid presenting molecules. They could specifically recognize self lipid antigens and extracellular lipid antigens, and present them to T lymphocytes. T lymphocytes are stimulated to secrete different cytokines to execute their immunological functions. CD1d, a member of CD1 family, exists both in human and
openaire   +1 more source

Regulation of multiple myeloma survival and progression by CD1d

Blood, 2009
Down-regulation of conventional human leukocyte antigen (HLA) class I and II molecules from the surface of tumor cells is an important mechanism for tumor immune evasion, survival, and progression. Whether CD1d, a nonconventional, glycolipid-presenting HLA class I–like molecule instructing the function of the immunoregulatory invariant NKT cells can ...
Emmanouil, Spanoudakis, Ming, Hu, Kikkeri, Naresh, Evangelos, Terpos, Valeria, Melo, Alistair, Reid, Ioannis, Kotsianidis, Saad, Abdalla, Amin, Rahemtulla, Anastasios, Karadimitris   +9 more
openaire   +2 more sources

Glycolipid Antigen Processing for Presentation by CD1d Molecules

Science, 2001
The requirement for processing glycolipid antigens in T cell recognition was examined with mouse CD1d-mediated responses to glycosphingolipids (GSLs). Although some disaccharide GSL antigens can be recognized without processing, the responses to three other antigens, including the disaccharide GSL Gal(α1→2)GalCer (Gal, galactose; GalCer ...
T I, Prigozy, O, Naidenko, P, Qasba, D, Elewaut, L, Brossay, A, Khurana, T, Natori, Y, Koezuka, A, Kulkarni, M, Kronenberg   +9 more
openaire   +2 more sources

Assignment of the evolutionarily conserved CD1D class gene (Cd1d) to rat chromosome 7q32

Cytogenetics and Cell Genetics, 2008
A, Matsuura, M, Kinebuchi, H, Chen, K, Yamada, M C, Yoshida, M, Horie, K, Kikuchi   +6 more
openaire   +2 more sources

The Regulation of CD1d+ and CD1d− Tumors by NKT Cells

2011
Jianyun Liu, Gourapura J. Renukaradhya, Randy R. Brutkiewicz   +2 more
openaire   +1 more source

A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies

Cell Reports Medicine, 2023
Iris De Weerdt, Roeland Lameris
exaly