Results 11 to 20 of about 136,322 (339)
Surface levels of CD20 determine anti-CD20 antibodies mediated cell death in vitro. [PDF]
PLoS ONE, 2014 The sensitivity of human Burkitt's lymphoma cells to rituximab (Rtx) and tositumomab (Tst) was assessed on cells expressing different levels of CD20 on surface.
Vijay Singh +5 more
doaj +5 more sources
CD20-positive adult T-cell leukemia [PDF]
American Journal of Hematology, 2000 A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expression of CD20 mRNA was also ...
Masaki Yasukawa +5 more
openalex +4 more sources
The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20 [PDF]
The Journal of Immunology, 2006 Abstract We have previously defined a panel of fully human CD20 mAb. Most of these were unexpectedly efficient in their ability to recruit C1q to the surface of CD20-positive cells and mediate tumor lysis via activation of the classical pathway of complement.
Paul W. H. I. Parren +13 more
openaire +4 more sources
Monoclonal antibodies targeting CD20 [PDF]
mAbs, 2013 Letter to the Editor: We are commenting on the article by Klein et al. on the functional properties of several anti-CD20 monoclonal antibodies (mAbs) in the January/February 2013 issue of this journal.1 Rituximab, the first monoclonal antibody approved for cancer therapy, has truly revolutionized the treatment of a variety of CD20+ hematological ...
Edmund A. Rossi +2 more
openaire +3 more sources
Mouse CD20 expression and function [PDF]
International Immunology, 2004 CD20 plays a role in human B cell proliferation and is an effective target for immunotherapy. In this study, mouse CD20 expression and biochemistry were assessed for the first time using a new panel of CD20-specific mAb, with CD20 function assessed using CD20-deficient (CD20(-/-)) mice.
Douglas A. Steeber +10 more
openaire +3 more sources
HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies [PDF]
Blood, 2017 Key Points HDAC6 inhibition represents a novel strategy to improve the efficacy of anti-CD20 mAbs. HDAC6 inhibition increases CD20 levels by enhancing CD20 protein synthesis without affecting the gene expression.
Kamil Bojarczuk +34 more
openaire +3 more sources
Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)
Креативная хирургия и онкология, 2020 This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov +2 more
doaj +1 more source
Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. [PDF]
, 2018 The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown ...
Bernard, Claude CA +9 more
core +1 more source
Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells [PDF]
, 2015 Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb).
Capuano, Cristina +8 more
core +1 more source
Gynecology and Minimally Invasive Therapy, 2020 Ovarian diffuse large B-cell lymphoma (DLBCL) is rare. DLBCL is a complex type of lymphoma. The ovarian DLBCL usually harbor a favorable prognosis. We report a case of ovarian DLBCL that presented as an ovarian mass with lower abdominal pain and was ...
Pei- Chen Li +3 more
doaj +1 more source