Results 21 to 30 of about 136,322 (339)

Targeting lentiviral vectors to antigen-specific immunoglobulins [PDF]

, 2008
Gene transfer into B cells by lentivectors can provide an alternative approach to managing B lymphocyte malignancies and autoreactive B cell-mediated autoimmune diseases.
Black M.E., David Baltimore, Davis T.A., Drake J.R., Dull T., Freeman S.M., Haiguang Yang, Kye il Joo, Leslie Ziegler, Lili Yang, Maloney D.G., Pin Wang, Rankin E.M., Reff M.E., Stripecke R., Vuist W.M., Wierda W.G., Yu J.H.   +17 more
core   +2 more sources

CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy

OncoImmunology, 2018
Since tumors are often infiltrated by macrophages, it would be advantageous to turn these types of cells into cytotoxic effector cells. Here, we have designed a novel bispecific antibody (BsAb) that targets both tumor antigen (CD20) and the FcαRI ...
Bingyu Li, Lijun Xu, Chenyu Pi, Yanxin Yin, Kun Xie, Fei Tao, Renhao Li, Hua Gu, Jianmin Fang   +8 more
doaj   +1 more source

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]

, 2018
Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni, Angela Santoni, Angela Santoni, Chiara Pighi, Cristina Capuano, Gabriella Palmieri, Lavinia Franchitti, Ombretta Turriziani, Ricciarda Galandrini, Simone Battella, Stefania Morrone   +10 more
core   +2 more sources

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production [PDF]

, 2017
Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16, represents one of the main mechanisms by which therapeutic antibodies
Battella, Simone, Belardinilli, Francesca, Capuano, Cristina, Galandrini, Ricciarda, Giannini, Giuseppe, Molfetta, Rosa, Palmieri, Gabriella, Paolini, Rossella, Pighi, Chiara, Santoni, Angela   +9 more
core   +2 more sources

Primary Angiitis of the Central Nervous System in Adults: A Comprehensive Review of 76 Biopsy-Proven Case Reports

Journal of Inflammation Research, 2023
Ping Lu,1 Lingyun Cui,1 Xinghu Zhang2 1Center for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Department of Neuroinfection and Neuroimmunology, Center for Neurology, Beijing Tiantan ...
Lu P, Cui L, Zhang X
doaj  

ANTI-B CELL THERAPY OF AUTOIMMUNE DISEASES

Медицинская иммунология, 2014
. Our understanding of the multiple physiological and pathological functions of B-cells continues to expand at a fascinating rate. As pathogenic elements in the development of autoimmune diseases, B-cells have become the focus of new therapeutics.
A. L. Masliansky, V. I. Mazurov, E. G. Zotkin, E. P. Ilivanova, Areg A. Totolian   +4 more
doaj   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source

90Yttrium Ibritumomab Tiuxetan (Zevalin) for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Report of 5 Cases

Blood and Lymphatic Cancer: Targets and Therapy, 2023
Jing Wang,1 Firas Baidoun,2 Han W Tun,2 Muhamad Alhaj Moustafa2 1Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, 32224, USA; 2Division of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, 32224 ...
Wang J, Baidoun F, Tun HW, Alhaj Moustafa M   +3 more
doaj  

Immunopathogenesis of canine chronic ulcerative stomatitis. [PDF]

, 2020
Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven.
Anderson, JG, Bizikova, P, Ford, K, Jimenez, RJ, Kol, A, Murphy, BG, Stapelton, BP, Vasilatis, D, Villarreal, A   +8 more
core   +1 more source

Features of Human CD3+CD20+ T Cells [PDF]

The Journal of Immunology, 2016
Abstract Monoclonal Abs against CD20 reduce the number of relapses in multiple sclerosis (MS); commonly this effect is solely attributed to depletion of B cells. Recently, however, a subset of CD3+CD20+ T cells has been described that is also targeted by the anti-CD20 mAb rituximab.
Elisabeth Schuh, Kerstin Berer, Matthias Mulazzani, Katharina Feil, Ingrid Meinl, Harald Lahm, Markus Krane, Rüdiger Lange, Kristina Pfannes, Marion Subklewe, Robert Gürkov, Monika Bradl, Reinhard Hohlfeld, Tania Kümpfel, Edgar Meinl, Markus Krumbholz   +15 more
openaire   +4 more sources