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TLR9 Inhibition Shortly After Mating Increases Fetal Resorption and Alters B- and T-Cell Costimulatory Phenotypes in an Abortion-Prone Mouse Model. [PDF]
Int J Mol SciLorek D +4 more
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Framework humanization enhances GM3(Neu5Gc)-targeting CAR-T cell function by reducing tonic signaling. [PDF]
Front ImmunolTu J +7 more
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An Innovative In Vivo Model for CAR-T-Cell Therapy Development: Efficacy Evaluation of CD19-Targeting CAR-T Cells on Human Lymphoma, Using the Chicken CAM Assay. [PDF]
Int J Mol SciWang Y +6 more
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Causal role of immunophenotypes in hepatocellular carcinoma: A Mendelian randomization study. [PDF]
Medicine (Baltimore)Ou D, Huo J.
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Current Opinion in Immunology, 1995
Until recently, it was thought that signal transduction through CD28 and the related molecule CTLA4 prevented the induction of anergy in T cells activated through the TCR. This hypothesis has been suggested as an explanation for how soluble forms of CTLA4, which bind the CD28/CTLA4 ligands B7-1 and B7-2, can prevent graft rejection.
L H, Boise, P J, Noel, C B, Thompson
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Until recently, it was thought that signal transduction through CD28 and the related molecule CTLA4 prevented the induction of anergy in T cells activated through the TCR. This hypothesis has been suggested as an explanation for how soluble forms of CTLA4, which bind the CD28/CTLA4 ligands B7-1 and B7-2, can prevent graft rejection.
L H, Boise, P J, Noel, C B, Thompson
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Nature Reviews Immunology, 2002
The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells.
Arlene H, Sharpe, Gordon J, Freeman
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The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells.
Arlene H, Sharpe, Gordon J, Freeman
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Targeting CD4+CD28− T cells by blocking CD28 co-stimulation
Trends in Molecular Medicine, 2013In the August issue of Trends in Molecular Medicine, Broux et al. [1] discussed the potential mechanisms underlying the expansion of CD4+CD28− T lymphocytes (a population of effector memory cells with cytotoxic capacity and pathogenic potential) in patients with immune-related diseases, including rheumatoid arthritis (RA) [1].
Paolo, Airò, Mirko, Scarsi
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2018
CD28 was identified in early 1980s by Martin and colleagues by monoclonal antibodies recognizing a 44 kDa protein on the surface of human T lymphocytes (Martin et al. 1980). Further experiments from Gmunder and Lessener evidenced the crucial role of this molecule in costimulating T cell responses by synergizing with PHA in inducing T cell proliferation
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CD28 was identified in early 1980s by Martin and colleagues by monoclonal antibodies recognizing a 44 kDa protein on the surface of human T lymphocytes (Martin et al. 1980). Further experiments from Gmunder and Lessener evidenced the crucial role of this molecule in costimulating T cell responses by synergizing with PHA in inducing T cell proliferation
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Genetic Analysis of CD28 Signaling
Immunologic Research, 2003T cell activation is central to initiating an immune response. Two signals are required: an antigen-specific signal through the T cell receptor (TCR) and an antigen-independent costimulatory signal, primarily through CD28 in naïve T cells. Although many of the molecules involved in TCR signal transduction have been identified, the signaling pathways ...
Tiffani A, Greene +1 more
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CD28/B7 Costimulation: A Review
Critical Reviews™ in Immunology, 1998The current model of T cell activation requires two signals. The first signal is specific, requiring T cell receptor recognition and binding to MHC/Antigen presented by an antigen-presenting cell. The second signal is nonspecific, resulting from the binding of B7 ligand on the antigen-presenting cell with its receptor, CD28, on the T cell.
E A, Greenfield +2 more
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