Results 231 to 240 of about 107,086 (298)

The bidirectional genetic causality between immunocyte phenotypes and dilated cardiomyopathy: A bidirectional Mendelian randomization study. [PDF]

Medicine (Baltimore)
Feng W, Chang X, Li Q, Dong Z, Jin G, Huang J, Fan G, Xing Z, Wang Y.   +8 more
europepmc   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, EarlyView.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Phase 1/1b open-label, first-in-human study of HER2×CD3×CD28 trispecific T-cell engager (SAR443216) in participants with R/R HER2-expressing solid tumors. [PDF]

J Immunother Cancer
Dumbrava EE, Oh DY, Ryu MH, Calvo E, Garralda E, Chung WP, Bai LY, Rojas K, Yildirim O, Masciari S, Mi G, Wang L, Rotolo F, Gailhac S, Attieh E, Kanlikilicer P, Buday B, Perez R, Rharbaoui F, Abbadessa G, Moreno V.   +20 more
europepmc   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, EarlyView.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Beta-lactam antibiotics have immunomodulatory effects in vitro, including changes consistent with sepsis-induced immunosuppression. [PDF]

Crit Care
Snow TAC, Charoenpong S, Kim H, Carthigesan K, Gallagher L, Elkhodair S, Avraham R, Das A, Singer M, Brealey D, Arulkumaran N, University College London Hospitals Critical Care Research Team.   +11 more
europepmc   +1 more source

A PD1‐CD137L Fusion Protein More Potently Enhances Anti‐Tumour Immune Responses Than Targeting PD‐L1 and CD137 Separately

Immunology, EarlyView.
A PD1‐CD137L fusion protein converts the immunoinhibitory PD‐L1 to an immunostimulatory signal and is more effective than targeting PD‐L1 and CD137 separately. ABSTRACT Tumour immune evasion frequently involves PD‐L1‐mediated inhibition of T cell activity, limiting the efficacy of PD1/PD‐L1 blockade, particularly in PD‐L1‐low or immunologically ‘cold ...
Runze Xia, Emily Pauline Nickles, Yu Mei, Thamizhanban Manoharan, Yi Tian Png, Beijia Liu, Rui Sun, Kang Yi Lee, Gloryn Chia, Chwee Ming Lim, Herbert Schwarz   +10 more
wiley   +1 more source

Beta-Glucan Supplementation Improves Clinical Outcomes and Preserves Immune Homeostasis in Patients with Advanced Solid Tumors Receiving Chemotherapy: A Prospective Phase II Randomized Three-Arm Clinical Trial. [PDF]

Int J Mol Sci
Yang WC, Huang MS, Tsai YH.
europepmc   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers. [PDF]

Nat Commun
Ponnusamy K, Karaxhuku K, Jiang Y, Randzavola L, Ren H, Leontari I, Lye B, Zaidi M, Bartlett EJ, Tate EW, Pardalis V, Leonardos D, Nadafi R, Sarkar I, Reijmers RM, Bua M, Atta M, Katsarou A, Roberts IA, Chaidos A, Karadimitris A.   +20 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source