Results 251 to 260 of about 107,086 (298)
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Current Opinion in Immunology, 1995
Until recently, it was thought that signal transduction through CD28 and the related molecule CTLA4 prevented the induction of anergy in T cells activated through the TCR. This hypothesis has been suggested as an explanation for how soluble forms of CTLA4, which bind the CD28/CTLA4 ligands B7-1 and B7-2, can prevent graft rejection.
L H, Boise, P J, Noel, C B, Thompson
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Until recently, it was thought that signal transduction through CD28 and the related molecule CTLA4 prevented the induction of anergy in T cells activated through the TCR. This hypothesis has been suggested as an explanation for how soluble forms of CTLA4, which bind the CD28/CTLA4 ligands B7-1 and B7-2, can prevent graft rejection.
L H, Boise, P J, Noel, C B, Thompson
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Nature Reviews Immunology, 2002
The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells.
Arlene H, Sharpe, Gordon J, Freeman
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The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells.
Arlene H, Sharpe, Gordon J, Freeman
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Targeting CD4+CD28− T cells by blocking CD28 co-stimulation
Trends in Molecular Medicine, 2013In the August issue of Trends in Molecular Medicine, Broux et al. [1] discussed the potential mechanisms underlying the expansion of CD4+CD28− T lymphocytes (a population of effector memory cells with cytotoxic capacity and pathogenic potential) in patients with immune-related diseases, including rheumatoid arthritis (RA) [1].
Paolo, Airò, Mirko, Scarsi
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Novel mechanism of signaling by CD28
Immunology Letters, 2010Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling.
Elisa, Bjørgo, Kjetil, Taskén
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Genetic Analysis of CD28 Signaling
Immunologic Research, 2003T cell activation is central to initiating an immune response. Two signals are required: an antigen-specific signal through the T cell receptor (TCR) and an antigen-independent costimulatory signal, primarily through CD28 in naïve T cells. Although many of the molecules involved in TCR signal transduction have been identified, the signaling pathways ...
Tiffani A, Greene +1 more
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The Journal of Immunology, 1993
Abstract Costimulatory molecules on the APC regulate T cell growth by providing signals that regulate responses to TCR occupancy. One such molecule is B7/BB-1, which triggers a T cell activation pathway by binding the CD28 and/or CTLA-4 cell-surface molecules.
P S, Linsley +4 more
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Abstract Costimulatory molecules on the APC regulate T cell growth by providing signals that regulate responses to TCR occupancy. One such molecule is B7/BB-1, which triggers a T cell activation pathway by binding the CD28 and/or CTLA-4 cell-surface molecules.
P S, Linsley +4 more
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The B7 and CD28 receptor families
Immunology Today, 1994Current evidence suggests that T-cell receptor (TCR) recognition of antigen bound to the major histocompatibility complex (Ag-MHC) is insufficient to lead to T-cell proliferation or effector function. For a helper T cell to produce sufficient interleukin 2 (IL-2) to allow autocrine-driven clonal expansion, there is a requirement for so-called 'co ...
C H, June +3 more
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Nature Reviews Immunology, 2019
Computational modelling predicts a co-stimulatory role for Toll-like receptor 5 (TLR5) in naive CD4+ T cell activation.
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Computational modelling predicts a co-stimulatory role for Toll-like receptor 5 (TLR5) in naive CD4+ T cell activation.
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