Results 241 to 250 of about 107,086 (298)

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program. [PDF]

open access: yesNat Immunol
Postat J   +21 more
europepmc   +1 more source

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis. [PDF]

open access: yesElife
Georgiev P   +14 more
europepmc   +1 more source

CD28

open access: yes, 2018
CD28 was identified in early 1980s by Martin and colleagues by monoclonal antibodies recognizing a 44 kDa protein on the surface of human T lymphocytes (Martin et al. 1980). Further experiments from Gmunder and Lessener evidenced the crucial role of this molecule in costimulating T cell responses by synergizing with PHA in inducing T cell proliferation
luigi racioppi   +13 more
core   +3 more sources

CD28/B7 Costimulation: A Review

Critical Reviews in Immunology, 1998
The current model of T cell activation requires two signals. The first signal is specific, requiring T cell receptor recognition and binding to MHC/Antigen presented by an antigen-presenting cell. The second signal is nonspecific, resulting from the binding of B7 ligand on the antigen-presenting cell with its receptor, CD28, on the T cell.
Vijay Kuchroo   +2 more
exaly   +3 more sources

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