Results 261 to 270 of about 142,249 (285)
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The Journal of Immunology, 1993
Abstract Costimulatory molecules on the APC regulate T cell growth by providing signals that regulate responses to TCR occupancy. One such molecule is B7/BB-1, which triggers a T cell activation pathway by binding the CD28 and/or CTLA-4 cell-surface molecules.
P S, Linsley +4 more
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Abstract Costimulatory molecules on the APC regulate T cell growth by providing signals that regulate responses to TCR occupancy. One such molecule is B7/BB-1, which triggers a T cell activation pathway by binding the CD28 and/or CTLA-4 cell-surface molecules.
P S, Linsley +4 more
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Proliferation and apoptosis of human CD8+CD28+ and CD8+CD28− lymphocytes during aging
Experimental Gerontology, 2004It is commonly believed that the age-related decrease in the ratio CD28(+)/CD28(-) among CD8(+) T cells reflects replicative senescence of the lymphocytes. To verify this claim we measured the proliferation of CD8(+)CD28(+) and CD8(+)CD28(-) subsets by flow cytometry after PHA treatment of mononuclear lymphocytes from donors of different age, including
Agnieszka, Brzezińska +3 more
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CD28 - OLD DOG, NEW TRICKS: CD28 IN PLASMA CELL/MULTIPLE MYELOMA BIOLOGY
2008The concept of a costimulatory signal requirement for immune cell activation has been attributed to Bretscher and Cohn, 7 who first proposed that B cell activation required two signals. This model was subsequently modified by Lafferty and Cunningham for T cell activation and allograft rejection.
Jayakumar R, Nair +2 more
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Novel mechanism of signaling by CD28
Immunology Letters, 2010Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling.
Elisa, Bjørgo, Kjetil, Taskén
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Molecular characterization of Cynoglossus semilaevis CD28
Fish & Shellfish Immunology, 2012T lymphocyte activation requires a combination of signals, one of which is provided by interaction between CD28 and its ligands on antigen presenting cells. Although CD28-like sequences have been identified in a few teleosts, the function of fish CD28 is virtually unknown.
Yong-hua, Hu +3 more
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Nature Reviews Immunology, 2019
Computational modelling predicts a co-stimulatory role for Toll-like receptor 5 (TLR5) in naive CD4+ T cell activation.
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Computational modelling predicts a co-stimulatory role for Toll-like receptor 5 (TLR5) in naive CD4+ T cell activation.
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